Cigarette smoking 1600 INDEX

The relationship of PbB level to systolic and diastolic blood pressure was determined in a study of 89 Boston policemen (race not specified) (Weiss et al. 1986, 1988). These policemen were under observation for health outcomes related to environmental work exposures (i.e., they had traffic exposure histories). After statistically adjusting for previous systolic blood pressure, body mass index, age, and cigarette smoking, high PbB level ( 30 pg/dL) was a significant (p=0.01) predictor of subsequent elevation in systolic blood pressure of 1.5-11 mm Hg in the working policemen with normal blood pressure. Low PbB level (20-29 pg/dL) was not a predictor of subsequent systolic blood pressure elevations. Diastolic pressure was unrelated to PbB levels. 

A study of 398 male and 133 female civil servants in London, England, measured blood pressure, PbB, and serum creatinine concentration the study found no correlation between blood pressure and PbB after adjustment for significant covariates, including sex, age, cigarette smoking, alcohol intake, and body mass index in a stepwise multiple regression analysis (Staessen et al. 1990). 

Radford, E. P., and E. A. Martell, Polonium-210 lead-210 ratios as an index of residence times of insoluble particles from cigarette smoke in bronchial epithelium, in Inhaled Particles IV, Part 2 (W. H. Walton, ed.) pp. 567-580, Pergamon Press, Oxford (1977). 

Cyanide in the body is biotransformed to thiocyanate quickly. People may also be exposed to thiocyanate from dietary, industrial, and medical sources. The plasma concentration of thiocyanate has also been used as an index of long-term exposure to cigarette smoke (Liu and Yun 1993). Some authors have determined thiocyanate in body fluids as a measure of cyanide exposure, while others measure cyanide concentrations in body fluids as a measure of cyanide exposure. 

Based on current information, inhibitors of CYP 1A2 have the greatest potential for causing interactions with olanzapine. Examples include cimetidine, fluvoxamine, and fluoroquinolone antibiotics (e.g., ciprofloxacin) to varying degrees. To date, however, no serious inhibition interactions have been reported with olanzapine, which may be a result of olanzapine s wide therapeutic index. Carbamazepine has been reported to increase olanzapine elimination by as much as 50%. Cigarette smoking is a potent inducer of CYP 1A2, and one would expect lower mean olanzapine serum concentrations in smokers compared to nonsmokers. 

Scassellati-Sforzolini, G. and A. Savino Valutazione di un indice rapido di contaminazione ambientale da fumo di zigaretta in relazione alle composizione della fase del fumo [Evaluation of a rapid index of ambient contamination by cigarette smoke in relation to the composition of gas phase of smoke] Riv. Ital. Ig. 28 (1968) 43-55. 

Fischer, S., B. Spiegelhalder, and R. Preussmann Tobacco-specific nitrosamines in mainstream smoke of West German cigarettes Tar alone is not a sufficient index for the carcinogenic potential of cigarettes Carcinogenesis 10 (1989) 169-173. 

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