Chronic lymphocytic leukemia staging

Chemotherapy does not improve overall survival in early-stage chronic lymphocytic leukemia (CLL). 

Patients with early-stage chronic lymphocytic leukemia (CLL) have a relatively good prognosis, and therapy has not changed the course of the disease. However, in the setting of high-risk disease or in the presence of disease-related symptoms, treatment is indicated. 

B cell neoplasms based on morphology, immunophenotype, and genotype often, but not always, correspond to stages of B cell development. However, some B cell lymphomas either do not clearly correspond to a specific developmental stage (i.e., appear to be of variable origin such as chronic lymphocytic leukemia/small lymphocytic lymphoma) or do not appear to be related to any known stage of normal development (i.e., hairy cell leukemia) (H10). 

Lymphoid Tumors. Lymphoid tumors, such as lymphomas or chronic lymphocytic leukemias, arise from less mature stages in B-lymphocyte development about one in five produce paraproteins, usually of the IgM class. 

TABLE 132—3. Rai Staging System for Chronic Lymphocytic Leukemia... 

NCT00262743 A phase I/II study of daily oral Polyphenon E in asymptomatic, Rai stage O-II patients with chronic lymphocytic leukemia... 

Shanafelt TD, Call TG, Zent CS, LaPlant B, Bowen DA, Roos M, Secrete CR, Ghosh AK, Rabat BE, Lee Ml, Yang CS, Jelinek DF, Erlichman C, Kay NE (2009) Phase I trial of daily oral Polyphenon E in paticaits with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia. J Clin Oncol 27 3808-3814... 

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