Chronic lymphocytic leukemia prognosis

Calin GA, Ferracin M, Cimmino A et al (2005) A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 353 1793-1801... 

Patients with early-stage chronic lymphocytic leukemia (CLL) have a relatively good prognosis, and therapy has not changed the course of the disease. However, in the setting of high-risk disease or in the presence of disease-related symptoms, treatment is indicated. 

B-cell chronic lymphocytic leukemia (B-CLL) MiR-123,miR-220,and miR-192 down MiR-190,miR-183-prec,miR-33,miR-19a,miR-140,miR-123,miR-10b,miR-15b-prec,miR-92-l, miR-188, miR-l 54, miR-227, miR-101,miR-141-prec,miR-153-prec,miR-196-2,miR-134,miR-141,miR-132,and miR-181b-prec Microarray, confirmed by northern blot and realtime RT-PCR miRNA profiles are associated with biological behavior and prognosis in B-CLL 146... 

McCarthy, J., Wierda, W. G., Barron, L. L., Cromwell, C. C., Wang, J., Coombes, K. R., Rangel, R., Elenitobajohnson, K. S., Keating, M. J., and Abruzzo, L. V. (2003). High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia. Blood 101, 4903-4908. 

The 12% of lymphoma and 10% of chronic lymphatic leukemia with paraproteins may actually represent neoplasia of the B-lymphocyte line (bursa-equivalent), i.e., true plasma cell precursors. The prognosis... 

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