Chromosome male mouse

Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A (2003c) H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell 4 497—508... 

The inactive heterochromatic X-chromosome of C. elegans in males and hermaphrodites is devoid of H3 methyl Lys-4. Further the male single X-chromosome has H3 methyl Lys-9, which is not observed in the X-chromosomes of the hermaphrodite [169]. Male mouse XY bodies were also found to have high levels of H3 methyl Lys-9. 

One such case involved investigation of the linkage between two different mouse idiotypes (A5A and ARS), both linked to the A/J Ch allotype . The observation of a crossover between the ASA idiotype and the BALB/c allotype in one male mouse provided the opportunity to test linkage between these two idiotypes. The crossover mouse was bred and the new haplotype (allogroup) was shown to be inherited without the ARS idiotype. On the basis of these data, the chromosomes of the BALB/c, A/J and recombinant might be represented ... 

Observations on Meiotic Chromosomes of the Male Mouse as a Test of the Potential Mutagenicity of Chemicals in Mammals ... 

Nickel water-soluble salts were also reported to induce chromosome aberrations in CHO cells [444, 445] and in mouse mammary carcinoma cells [260, 446], Changes in growth control and chromosome aberrations in human bronchial cells were demonstrated in vitro after exposure to nickel sulphate the changes were insufficient to cause the cells to be tumourigenic [447], Nickel chloride was unable to produce chromosome aberrations in vivo in mammalian male germ cells [448],... 

Exposure to neither cresol isomer had any effect on the occurrence of dominant lethal mutations in mice (Hazleton Labs 1989a, 1989b). m-Cresol was tested for ability to induce chromosomal aberrations in mouse bone marrow in Vivo. Male and female mice were given a single dose of 0, 96, 320, or 960 mg/kg by gavage in corn oil and sacrificed after 6, 24, and 48 hours for extraction and examination of bone marrow. No effect on chromosomal aberrations was found (Hazleton Labs, 1989c). 

Di(2-ethylhexyl) adipate did not bind covalently to mouse liver DNA in vivo. One report showed evidence of oxidative damage in rat liver DNA in vivo but not in rat kidney DNA. A weak dominant lethal effect has been reported in male mice. Analyses of mouse bone marrow after treatment with di(2-ethylhexyl) adipate in vivo found no induction of micronuclei in one study and no induction of chromosomal aberrations in one study. Urine from rats treated with di(2-ethylhexyl) adipate by gavage was not mutagenic to Salmonella typhimurium. 

In one in-vivo study, induction of chromosomal aberrations in mouse bone-marrow cells and dominant lethal effects in male mice and rats were reported, following exposures to atmospheres containing any low concentration of chloroprene. Another in-vivo study, in which mice were exposed to atmospheres ranging up to 200 ppm [720 mg/m ] chloroprene (a lethal concentration), found no induction of sister chromatid exchanges or chromosomal aberrations in bone-marrow cells or micronuclei in circulating blood cells. 

Convenient methods378 exist in the mouse for detecting whole-chromosome aneuploidy, as determined by sex-chromosome loss and nondisjunction, ttiese methods are possible because XO female mice and XXY male mice are viable. 

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