Chromatography screening methods

Nitrate can also be measured potentiometrically with an ion-selective electrode at 10 10 M (24,25). This method is suggested as a screening method for determining the approximate nitrate concentration (20). Ion chromatography can be used for nitrate concentrations of 2 to 10 ppb (23). 

Thin-layer chromatography is an excellent screening method because ... 

TLC is a screening method a small percentage (5 to 10%) of the samples should be confirmed by a more sophisticated analytical method such as gas chromatography or high performance liquid chromatography... 

X. Xu, A.M. van der Craats and P.C.A.M. de Bmyn, Highly sensitive screening method for nitroaromatic, nitramines and nitrate ester explosives by high performance liquid chromatography — atmospheric pressure ionization — mass spectrometry (HPLC-APl-MS) in forensic applications , J. Forensic Sci., 49 No. 6 (2004) 1171-1180. 

Lee KC, Chan W, Liang Z, Liu N, Zhao Z, Lee AW, Cai Z (2008) Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry in negative ion mode. Rapid Commun Mass Spectrom 22 2825-2834... 

Pulsed ultrafiltration MS (PUF-MS) represents an inline high throughput affinity screening method with a variety of potential uses in the discovery and development of pharmaceuticals [22]. The in-line combination of solution-phase equilibration, ultrafiltration, and electrospray liquid chromatography mass spectrometry (LC-ESI-MS) facilitates the identification of high affinity target-specific... 

Most of the analytical methods for the analysis of pesticides in food are based on instrumental approaches based on chromatography coupled to mass spectrometry. However, a great effort of development has been paid to develop rapid screening methods based on biological methods, such as, enzyme linked immunosorbent assays (ELISA). 

Thin-Layer Chromatography. Thin-layer chromatography was used for many of the compounds which are of interest for either qualitative or quantative analysis. These techniques were used primarily as screening methods to supplement other analytical methods. For some brominated compounds such as TRIS, the detection system reported by Hahn (9) was applicable. This method is based upon the reaction of fluorescein with elemental bromine released through peroxide oxidation. An evaluation in our laboratory of this detection system indicated that semi-quantitative results... 

Tolonen, A. and Uusitalo, L, Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry with polarity switching. Rapid Commun. Mass Spectrom., 18, 3113, 2004. 

Toyo oka T, Kashiwazaki T, Kato M. On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection. Talanta. 2003 60 467-475. 

Schroyer, B. and P. Capel (1996). A high-performance liquid chromatography-based screening method for the analysis of atrazine, alachlor, and ten of their transformation products. In M.T. Meyer and E.M. Thurman, eds., Herbicides Metabolites in Surface Water and Ground Water. ACS Symposium Series 630. Washington, DC American Chemical Society, pp. 34-42. 

Leblanc, C.J., W.M. Stallard, P.G. Green, and E.D. Schroeder. 2003. Passive sampling screening method using thin-layer chromatography plates. Environ. Sci. Technol. 37 3966-3971. 

Deventer K, Delbeke FT (2003) Validation of a quantitative screening method for corticosteroids by liquid chromatography tandem mass spectrometry. In Shanzer W, GeyerH, Gotzmann A, Mareck U (eds) Recent advances in doping analysis, vol 11, Spert and Buch Straub, Koln,... 

Biltehorn, U. and Pyell, U. (1996) Micellar electrokinetic chromatography as a screening method for the analysis of vanilla flavourings and vanilla extracts. Journal of Chromatography A 736(1-2), 321-332. 

Micellar electrokinetic chromatography was used as a fast screening method for the determination of 1,4-dihydropyridines, and was used for the separation of six drugs of this group including nimodipine [38]. A fused silica tube (58.5 cm x 75 pm i.d., 50 cm to detector) was operated at 25 kV with detection at 200-236 nm. The optimized buffer (pH 8.2) contained 20 mM SDS in 50 mM borate buffer modified with acetonitrile. Linear calibration graphs extended upto 70 pg/mL from lower limits of 6.7 pg/mL. 

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