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Chromatography artificial membrane

Pidgeon, C., Venkataram, U. V. Immobilized artificial membrane chromatography supports composed of membrane lipids. Anal. Eiochem. 1989,... [Pg.351]

Vrakas, D., Giaginis, C., Tsantili-Kakoulidou, A. Different retention behavior of structurally diverse basic and neutral drugs in immobilized artificial membrane and reversed-phase high performance liquid chromatography ... [Pg.351]

A very promising method, immobilized artificial membrane (IAM) chromatography, was developed by Pidgeon and co-workers [299-304,307], where silica resin was modified by covalent attachment of phospholipid-like groups to the surface. The retention parameters mimic the partitioning of drugs into phospholipid bilayers. The topic has been widely reviewed [47,298,307,309-311]. [Pg.54]

Ong, S. Liu, H. Pidgeon, C., Immobilized-artificial-membrane chromatography Measurements of membrane partition coefficient and predicting drug membrane permeability, J. Chromatogr. A 728, 113-128 (1996). [Pg.267]

This agrees to internal VolSurf models derived for PAMPA membrane transport [163] to understand passive transcellular transport across membranes. One of our internal models based on 29 compounds characterized by immobilized artificial membrane chromatography by Salminen etal. ]164] shows an of 0.81 and = 0.70 for two PLS components derived using VolSurf descriptors. This is one of the rare examples where ionized starting molecules led to slightly better PLS statistics, while the general chemical interpretation is not affected. [Pg.353]

JA Masucci, GW Caldwell, JP Foley. Comparison of the retention behavior of beta-blockers using immobilized artificial membrane chromatography and ly-sophospholipid micellar electrokinetic chromatography. J. Chromatogr. A 810 95-103 (1998). [Pg.84]

Barbato, F. (2006) The use of immobilised artificial membrane (lAM) chromatography for determination of lipophilicity. Current Computer-Aided Drug Design, 2, 341-352. [Pg.114]

Abraham, M. H., H. C. Chadha, R. A. E. Leitao, R. C. Mitchell, W. J. Lambert, R. Kaliszan, A. Nasal, and P. Haber, Determination of solute lipophilicity, as log P (octanol) and log P (alkane) using poly(styrene-divinylbenzene) and immobilized artificial membrane stationary phases in reversed-phase high performance liquid chromatography , J. Chromatogr. A, 766, 35-47 (1997). [Pg.1213]

Several studies have been undertaken to measure the retention times of compounds on chromatography columns comprising immobilized liposomes or artificial membranes. Liposomes comprise aqueous compartments surrounded by lipid bilayers, whereas the artificial membranes comprise monolayers of phospholipids (Lundahl and Beigi, 1997). Interaction between the compound and the phospholipids present mimics the interaction of compounds with cell membranes. Retention... [Pg.256]

Pidgeon C, Venkataram UV (1998) Immobilised artificial membrane chromatography Supports composed of membrane lipids. Anal Biochem 176 6-47... [Pg.465]

Stewart BH, Chan OH (1998) Use of immobilized artificial membrane chromatography for drug transport applications. J Pharm Sci 87 1471-1478 Taillardat-Bertschinger A, Carrupt PA, Barbato F et al. (2003) Immobilized artificial membrane HPLC in drug research. J Med Chem 46 655-665... [Pg.465]

The use of partition coefficients between water and lipophilic media is of wide use in pharmaceutical research. As discussed in the last chapters, different lipophilicity scales are used to describe the lipophilicity of a compound and relate it to its absorption behaviour in vivo. Differences between the logPow and partitioning between phospholipids and water (mainly determined using liposomes) for diverse compounds have been described leading to the development of the immobilized artificial membrane chromatography system. However, also the predictivity of the IAM system is limited and only a small number of membrane systems are available. [Pg.468]

Chromatography also can be used to predict permeability. The most widely used methods are immobilized artificial membrane chromatography (lAM) and immobilized liposome chromatography (ILC). [Pg.1409]

Pehourcq, F., Jarry, C. and Bannwarth, B. (2003) Potential of immobilized artificial membrane chromatography for lipophilicity determination of arylpropionic acid non-steroidal antiinflammatory drugs. Journal of Pharmaceutical and Biomedical Analysis,... [Pg.130]

Abraham, M.H., Chadha, H.S., Leitao, R.A.E., Mitchell, R.C., Lambert, W.J., Kaliszan, R. and Masai, H.P. (1997) Determination of solute lipophilidty, as log Poctanol and log Palkane Using polystyrene divinylbenzene and immobilised artificial membrane stationary phases in reversed-phase high-performance liquid chromatography. Journal of Chromatography A,... [Pg.130]

BH Stewart, OH Chan. Use of immobilized artificial membrane chromatography for drug transport applications. J Pharm Sci 87 1471—1478, 1998. [Pg.267]

See other pages where Chromatography artificial membrane is mentioned: [Pg.37]    [Pg.98]    [Pg.43]    [Pg.267]    [Pg.267]    [Pg.19]    [Pg.517]    [Pg.353]    [Pg.11]    [Pg.177]    [Pg.89]    [Pg.535]    [Pg.109]    [Pg.45]    [Pg.46]    [Pg.368]    [Pg.257]    [Pg.418]    [Pg.465]    [Pg.338]    [Pg.301]    [Pg.351]    [Pg.1409]    [Pg.558]    [Pg.71]    [Pg.83]    [Pg.250]    [Pg.252]   


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