Immobilised artificial membranes

Salminen T, Pulli A, Taskinen J (1997) Relationship between immobilised artificial membrane chromatographic retention and the brain penetration of structurally diverse drugs. J Pharm Biomed Anal 15 469-477. 

Barbato, F. (2006) The use of immobilised artificial membrane (lAM) chromatography for determination of lipophilicity. Current Computer-Aided Drug Design, 2, 341-352. 

Ong, S., Liu, H., and Pidgeon, C., Immobilised-artificial-membrane chromatography measurements of membrane partition coefficients and predicting drug membrane permeability, J. Chromatogr. A, 728,113-128, 1996. 

Pidgeon C, Venkataram UV (1998) Immobilised artificial membrane chromatography Supports composed of membrane lipids. Anal Biochem 176 6-47... 

The separation technique can be used in two different ways for the measurements of physico-chemical parameters. In one approach the propenies of the compounds are characterised directly from the chromatographic retention which is determined by the interaction of solutes with the stationary and the mobile phases. This approach can be used for lipophilicity determination, measurements of serum albumin binding and estimating the membrane transport of compounds from their retention on immobilised artificial membrane. 

TaiUardt-Bertschinger A, Martinet CAM, Canupt PA, Reist M, Caron G, Fiuttero R, and Testa B. Molecular factors influencing retention on immobilised artificial membranes (lAM) compared to partitioning in liposomes and n-octanol. Pharm. Res. 2002 19 (6) 729-737. 

Abraham, M.H., Chadha, H.S., Leitao, R.A.E., Mitchell, R.C., Lambert, W.J., Kaliszan, R. and Masai, H.P. (1997) Determination of solute lipophilidty, as log Poctanol and log Palkane Using polystyrene divinylbenzene and immobilised artificial membrane stationary phases in reversed-phase high-performance liquid chromatography. Journal of Chromatography A,... 

Valko, K., Plass, M., Bevan, C., Reynolds, D. and Abraham, M.H. (1998) Relationships between the chromatographic hydrophobicity indices and solute descriptors obtained by using several reversed-phase, diol, nitrile, cyclodextrin and immobilised artificial membrane bonded high-performance liquid chromatography columns. 

Valkd KL, Nunhuck SB, Hill AP. 2001. Estimating unbound volume of distribution and tissue binding by in vitro HPLC-based human serum albumin and immobilised artificial membrane-binding measurements. J Pham Sci 100 849-862. 

Estimation of voliune of distribution in humans from high-throughput HPLC-based measiuements of human serum albumin binding and immobilised artificial membrane partitioning. Journal of Medicinal Chemistry, 49, 6958-6971. 

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