Chromatin organization

CHROMO Chromatin organization modifier domain E(MFP) 4(5) 23(29) 1AP0... 

Hofmann N, Hilscher B (1991) Use of aniline blue to assess chromatin condensation in morphologically normal spermatozoa in normal and infertile men. Hum Reprod 6 979-982 Howman EV, Fowler KJ, Newson AJ, Redward S, MacDonald AC, Kalitsis P, Choo KH (2000) Early disruption of centromeric chromatin organization in centromere protein A (Cenpa) null mice. Proc Natl Acad Sci U S A 97 1148-1153... 

Structural studies of the chromatin organization of integrated HlV-1 have identified two DNase 1-Hypersensitive Sites (HS4 and HS7) outside of the promoter/enhancer region in U3, that were likely to play a role in controlling viral transcription by virtue of their accessibility in chromatin (Fig. la and lb) (Verdin, 1991). 

Analysis of the chromatin organization of integrated HIV-1 identified a single major nuclease-hypersensitive site in the 8 kb region located between the two LTRs (Verdin, 1991 Van Lint et al, 1994). This hypersensitive site, centered around nt... 

A. S. Belmont, Large-scale chromatin organization, in Genome Structure and Function, Kluwer Academic Publishers, Dordrecht, 1997, p. 261. 

On the other hand, there is no question that enormous strides have been made. It is now possible to describe in detail the chromatin structures in many specific promoters, and then show how they are remodeled for transcriptional activation. Different kinds of chromatin organization are now recognized for different levels of developmental control. Despite the remarkable advance in detailed information that the past 25 years have provided, the overall picture of transcription in chromatin remains strangely obscured. There is almost too much... 

Chromatin organization and its relation to function in the intact cell have become part of a broader area of investigation, the organization of the cell nucleus itself. The suceess of modern molecular biology, which has focussed on the characterization of cis-elements in the DNA that affect nuclear events such as... 

Epigenetics and chromatin organization. Cell 2007 128(4). Entire issue. HEP, the Human Epigenome Project, http //www.epgenome.org. Insight Epigenetics. Nature 2007 447(7143). Entire issue. 

Carlberg, C. et al. (2007) Controlling the chromatin organization of vitamin D target genes by multiple vitamin D receptor binding sites. The Journal of Steroid Biochemistry and Molecular Biology, 103, 338-343. 

In general, the genome refers to the cell s DNA, DNA sequence, and chromatin organization. Transcriptome describes the cells complement of mRNA produced by the transcription of DNA sequences or genes, and the proteome is all cellular protein translated from the mRNA. The term metabonome refers... 

Volpi E.V., Chevret E., Jones T., Vatcheva R., Williamson J., Beck S., Campbell R.D., Goldsworthy M., Powis S.H., Ragoussis J., Trowsdale J., Sheer D. (2000). Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. J. Cell Sci. 113 1565-1576. 

Ding R, Smulson M. Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression Influences on genomic stability, chromatin organization and carcinogen cytotoxicity. Cancer Res 1994 54 4627-4634. 

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