Chorionic gonadotropin function

Morphologically, this is demonstrated by the development of a multinuclear syncytium with apical microvilli [49], while functional differentiation is associated with induction and synthesis of hormones, such as human chorionic gonadotropin (hCG) and human placental lactogen (hPL) [50, 51]. Cultures of primary cytotrophoblasts have been used to study functional expression of P-gp, amino acid uptake, and hormonal stimulation of amino acid uptake and... 

Allen W E 1983 The effect of human chorionic gonadotropin and exogenous progesterone on luteal function during early pregnancy in pony mares. Animal Reproduction Science 6 223-228... 

Figure 54-3 Concentration of chorionic gonadotropin (CG) in maternal serum as a function of gestational age. Lines represent the 2nd, 50th, and 97th percentiles.The maternal serum values from 14 to 25 weeks are medians calculated from 24,229 pregnancies from testing performed at ARUP Laboratories Inc, from January to October 1997, fRedrawn fromAshwood R. Evaluating health and maturation of the unborn the role of the clinical laboratory. Clin Chem 1992 38 1523-1529. Permission granted from Clin Chem.)...

Ngowngarmratana S, Sunthornthepvarakul T, Kanchanawat S. Thyroid function and human chorionic gonadotropin in patients with hydatidi-form mole. J Med Assoc Thailand 1997 80 693-699. 

If fertilization occurs, the corpus luteum remains viable and begins secretion of human chorionic gonadotropin (HCG), a function eventually taken over... 

Matias-Guiu X, Prat J. Ovatian tumots with functioning stroma. An immunohistochemical study of 100 cases with human chorionic gonadotropin monoclonal and polyclonal antibodies. Cancer. 1990 65 2001-2005. 

Nagayama, Y., Wadsworth, H.L., Chazenbalk, G.D., Russo, D., Seto, P. and Rapoport, B. (1991) Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for thyrotropin receptor function. Proc. Natl Acad. Sci. USA 88 902-905. 

Human chorionic gonadotropin mimics LH both in structure and in function. It is produced by the placenta during pregnancy and is isolated from the urine of pregnant women. In the protocols for lUI or IVF, exogenous hCG must be administered to stimulate a scheduled ovulation. Between 36 and 72 hours after intramuscular administration, the dominant follicle ruptures and releases its egg. At that point, the scheduled lUI or IVF occurs. The hCG can be given in combination with clomiphene citrate to enhance ovulation (95). (For an in-depth discussion of hCG, see Chapter 7.)... 

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