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Vapor pressure cholinesterase inhibitors

Althongh strnctural feature in the molecule varies from most other organophosphorus pesticides, the toxic actions are similar to parathion and other phosphate esters. Extremely toxic by all routes of exposure cholinesterase inhibitor can present a serious inhalation hazard, if spilled, due to relatively high vapor pressure exhibits acute, delayed, and chronic effects symptoms of cholinergic effects similar to those of other organophosphates death can result from respiratory arrest ingestion of 0.3-2 g could be fatal to adult human. [Pg.799]

Highly toxic cholinesterase inhibitor exhibits acute, delayed, and chronic poisoning exposure risk of inhalation of vapors, however, may be low because of its very low vapor pressure [3.0 x 10 torr at 20°C (68°F)] also, severity of toxicity may vary widely from species to species rats are more vulnerable to its effect than are mice or rabbits signs of toxicity in human include headache, dizziness, muscle spasms, tearing, blurred vision, salivation, vomiting, abdominal pain, diarrhea, chest pain, and convulsions high exposure can cause coma and death ingestion of 0.4-1 g can be lethal to adult humans. [Pg.801]

Carbaryl (1-naphthyl Af-methylcarbamate, Sevin [CAS 63-25-2]) A carbamate-type cholinesterase inhibitor (see p 291). Evidence of adverse effects on fetal development in test animals at high doses. 5 mg/m 100 mg/m Coloriess, white or gray solid. Odoriess. Vapor pressure is 0.005 mm Hg at 20°C (68°F). Breakdown products Include oxides ot nitrogen and methyl-amine. [Pg.547]

Carbofuran (2,3-dlhydro-2,2 -dimelhyl-7-benzofuranylmelhylcarba-mate, Furadan [CAS 1563-66-2]) A carbamate-type cholinesterase inhibitor (see p 291). Not well absorbed by skin contact. 0.1 mg/m White solid crystals. Odorless. Vapor pressure Is 0.00005 mm Hg at 33°C (91 °F). Thennal-break-down products Include oxides ot nitrogen. [Pg.547]

Demeton (Systox, mercaptophos [CAS 8065-48-3]) An organo- phosphate-type cholinesterase inhibitor (see p 291). 0.05 mg/m , S 10mg/m A sulfur-like odor. A very low vapor pressure at 20°C (68°F). Thermal-breakdown products include oxides of sulfur. [Pg.558]

Diazinon (0,0-diethyl 0-2-isopropyl-4-melhyl-6-pyiimidinylthio-phosphate [CAS 333-41-5]) An organophosphate-type cholinesterase inhibitor (see p 291). Well absorbed dermally. Limited evidence for adverse effects on male reproduction and fetal development in test animals at high doses. 0.1 mg/m , S Commercial grades are yellow to brown liquids with a faint odor. Vapor pressure is 0.00014 mm Hg at 20 C (68 F). Themnal-breakdown products include oxides of nitrogen and sulfur. [Pg.558]

DIchlorvos (DDVP, 2,2-dlchlorovlnyl dimethyl phosphate [CAS 62- 73-7]) An organophosphate-type cholinesterase inhibitor (see p 291), Extremely well absorbed through skin. Evidence of carcinogenicity In test animals (lARC 2B). 0.1 mg/m S, SEN 100 mg/m Colorless to amber liquid with a slight chemical odor. Vapor pressure is 0.032 mm Hg at 32°C (90 F). [Pg.563]

Fenthion (0,0-dimethyl 0-[3-methyl-4-(methylthio)phenyl]phos-phorolhioale [CAS 55-38-9]) An organophosphate-type cholinesterase inhibitor (see p 291). Highly lipid soluble toxicity may be prolonged. Dermal absorption is rapid. 0.2 mg/m S Yellow to tan viscous liguid with a mild garlic-like odor. Vapor pressure is 0.00003 mm Hg at 20°C (68°E). [Pg.575]

Methyl demeton (0,0-dimethyl 2-etbylmercaploelbyl Ibiopbos-phate [CAS 8022-00-21) An organophosphate-type cholinesterase inhibitor (seep 291). 0.5 mg/m , s Colodess to pale yellow liquid with an unpleasant odor. Vapor pressure Is 0.00036 mm Hg at 20°C (68°F). Thernial-breakdown products Include oxides of sulfur and phosphoms. [Pg.591]

Methyl patalhion (0,0-dimelhyl 0-p-nitro-phenylphosphorolhioale [CAS 298-00-0]) A highly potent organophosphate cholinesterase inhibitor (seep 291). 0.2 mg/m , S Tan liquid with a strong garlic-like odor. Vapor pressure is 0.5 mm Hg at 20°C (68°F). Appearance may vary with formulation. [Pg.594]

Telraelhyl pyrophosphale (TEPP [CAS 107-49-3]) A potent organo- phosphate cholinesterase inhibitor (see p 291), Rapidly absorbed through skin. 0.05 mg/m , S 5mg/m Colorless to amber liquid wllh a lalnl Irulty odor. Slowly hydrolyzed In water. Vapor pressure Is 1 mm Hg at 140°C (284°F). Not combustible. Thermal-breakdown products Include phosphoric acid mist. [Pg.619]

Properties Colorless clear vise, liq. mild odor sol. in most org. soivs., 95% ethanol, acetone, DMSO, ketones, chlorinated hydrocarbons sol. < 1 mg/ml in water insol. in aliphatic hydrocarbons m.w. 430.91 dens. 1.508 g/cm (22.2 C) vapor pressure 10.3 mm Hg (25 C) f.p. 27 C b.p. 236-237 C (5 mm) flash pt. 252 C ref. index 1.5022 Toxicology LD50 (oral, rat) 1850 mg/kg, (skin, rabbit) > 23,700 mg/kg mod. toxic by ing. may cause irritation of skin, respiratory tract cholinesterase inhibitor may cause tremors, convulsions, irritability, hypermotility, diarrhea, enzyme inhibition, change in blood/tissue levels, changes in liver/kidney wt questionable carcinogen experimental teratogen and reproductive effects mutagenic data ... [Pg.4513]


See other pages where Vapor pressure cholinesterase inhibitors is mentioned: [Pg.103]    [Pg.134]    [Pg.540]    [Pg.569]    [Pg.601]    [Pg.53]    [Pg.1599]    [Pg.2474]   
See also in sourсe #XX -- [ Pg.399 ]




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