Chlorpromazine other data

In addition, Platman (92) studied 13 patients on lithium and 10 on chlorpromazine (CPZ), finding lithium consistently superior overall, but not statistically significant on any individual rating scale. The general state of patients on lithium was markedly superior to those on CPZ because the majority were discharged with no other treatment, whereas all of the patients on CPZ required additional concurrent drugs. Because the author did not present data on individual patients, these results could not be included in our meta-analysis, but his results are also consistent with the outcome in Table 10-4. Due to the small sample size, the results should be interpreted cautiously. 

Some data indicate that nitrites exert their action by a mechanism other than methemoglobin formation. It has been suggested that the protective effect is due to the vasodilating effect of nitrite.52 Several a-adrenergic antagonists (eg, chlorpromazine, promethazine, promazine, and phenoxybenzamine) that cause vasodilation also antagonize cyanide toxicity.5657 Further information is needed to determine the mechanism or mechanisms by which chlorpromazine and phenoxybenzamine reverse cyanide intoxication.57... 

A case report describes a woman who had been taking chlorpromazine 100 mg three times daily for one week without problems when a combined oral contraceptive (ethinylestradiol/norgestrel) was started. Four days later she developed severe dyskinesias and tremor, and her chlorpromazine levels were found to have increased by about sixfold. This case was briefly mentioned in an earlier report by the same authors. The reasons are not understood but increased absorption or reduced liver metabolism of the phenothiazines are suggested. The general clinical importance of these findings is not known, and documentation is very limited. There seem to be no other reports of adverse reactions, and the available data are insufficient to justify any general precautions. Further study is needed. 

Section B (Fig. 17) shows some commonly used drugs which are electroactive. The a-methyltryptamine was detected at + 0.8 V by Marsden (1980) in 5-HT studies. Several monoamine oxidase inhibitors are electroactive, but there is so far no evidence that they can be detected in vivo and, even if they are, it is at potentials sufficiently positive not to interfere with most studies. Chlorpromazine and haloperidol have solution Ep values about + 0.6 V and + 0.7 V, respectively. Clozapine oxidizes at about + 0.4 V. Since neuroleptics (and other drugs) are extensively metabolized by the time they appear in significant concentrations in the CNS, the potentials of the parent compounds may not be too relevant—but no data are available for metabolites. In any event, there is no evidence that any of these drugs are detected in CNS voltammetry. 

Multi-cellular Biochemical Synaptology - While it is clear from the previous material that the critical assessment of neurotransmitter functions for ACh, NE, or 5-HT Is almost completely lacking, it Is also clear that these deficiencies are technical. On the other hand a variety of drugs such as reserpine , amphetamlne, imipramine , chlorpromazine and various psychotomimetics l,122 appear to be involved with the neuronal metabolism of NE and 5-HT. It may be tentatively inferred, then, that biochemical studies of the metabolism of these substances, vdien interpreted In the light of the previous data, may help to provide insight into... 

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