Chlorpheniramine enantiomers

Chtmkvetadze B, Pin tore G, Bergenthal D, Buijanadze N, Strickmann D, Cerii R, Blaschke G (1998) Capdlaty electrophoresis, nuclear magnetic resonance and mass-spectrometric studies of opposite chiral recognition of chlorpheniramine enantiomers with various cyclodextrins. Electrophoresis 19 2101—2108... 

Hiep, B.T., Khanh, V., Hung, N.K., Thuillier, A., Gimenez, F. (1998). Determination of the enantiomers of chlorpheniramine and its main monodesmethyl metabolite in urine using achiral-chiral liquid chromatography. J. Chromatogr. B 707, 235-240. 

As with the other protein-based CSPs, initial studies indicate a relationship between the structure of the protein and chromatographic properties of the OVM CSP (101). When the sialic acid residues, were enzymatically removed from the protein, the capadty factors (k ) of the enantiomers of an addic solute (ketoprofen) were reduced, whereas the k s of the enantiomers of a basic solute (chlorpheniramine) were un-... 

Hagineika, J. Murashima, T. Fujima, H. Wada, H. Direct injection assay of drug enantiomers in serum on ovomucoid-bonded silica materials by liquid chromatography. J.Chromatogn, 1993,620,199—204 [direct injection serum chiral also benzoin, chlorpheniramine, oxazepam]... 

In a pharmacokinetic assessment, the H2 antagonist, ranitidine, was shown not to interact with either enantiomer after administration of ( )-chlorpheniramine [220]. 

A number of enantiomers (aminoglutethimide, chlorpheniramine, chlorthalidone, fluoxetine, ibuprofen, ketoprofen, methylphenidate, metoprolol, phensuximide, propranolol, suprofen and mephenytoin) were separated on a -cyclodextrin column using 40/60 to 20/80 acetonitrile/water (0.1% triethylammonium acetate pH 4.1 or 7.1) mobile phase (analyte dependent) [1550]. 

Protein can be added to the solution of precursor in order to add some biocomponent to the CEC column. Chiral compormds, bovine serum albumin (BSA) and ovomucoid (OVM) have been trapped within such sol-gel CEC in order to check their chiral selectivity. These capillary columns showed good enantioselectivity toward selected enantiomers such as tryptophan, benzoin, eperisome or chlorpheniramine (Kato, 2002). 

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