Chlorophenoxy toxicity

Chemical/Physical. Hydrolyzes in strong acids and bases forming 4-(4-chlorophenoxy)aniline (Hartley and Kidd, 1987). Emits toxic fumes of nitrogen oxides, cyanides, and chlorine when heated to decomposition (Sax and Lewis, 1987). 

The potential for environmental contamination continues to come from families of herbicides that have been used for years. The chlorophenoxy herbicides such as 2,4-D (2,4-dichlorophenoxy acetic acid) and 2,4,5-T (2,4,5-trichlorophenoxy-acetic acid) (Figure 5.1) are systemic acting compounds to control broadleaf plants and have been in use since the 1940s. The oral toxicities of these compounds are low. 

The widely used chlorophenoxy herbicides are chemical teratogens--as are their byproduct chlorodibenzodioxins. The symmetrical tetrachloro compound TCDD is perhaps the most toxic chemical known. 

Methomyl Chlorophenoxy compounds Chronic toxicity, mutagenicity... 

Chlorophenoxy herbicides exhibit low mammalian toxicity. The acute oral LD50 for 2,4-D in rats is > 300 mg kg Dogs are more susceptible to 2,4-D... 

Chlorophenoxy herbicides are moderately toxic to nontarget species. Some of the commercial products are highly toxic to aquatic invertebrates and other beneficial nontarget plants. 

Low levels of an applied herbicide-pesticide-solvent mix were drawn into the uptake air of a commercial building following the application of a pesticide mix to the lawn in front of that building. Several employees immediately reported CNS and respiratory symptoms, with one sustaining a permanent respiratory injury. The pesticide mix applied to the lawn was composed of 2,4-D (2.82), 2-(2-methyl-4-chlorophenoxy) propionic acid (MCPP 2.48), and dicamba (2.21). The mixture also contained solvent naphtha (a mixture of aliphatic solvents, Kqw = 3.5-5.0) with 14% naphthalene (2.48) and dinitroaniline (3.30). The concentrations of all pesticides and solvents were far below the TLVs both outside and inside the building. The toxic effects observed were ascribed to the mixture of lipophilic and hydrophilic pesticides. 441... 

Chlorophenoxy herbicides are, by themselves, of relative low toxicity to humans. They are, however, often contaminated with dioxins, of which, 2,3,7,8-tetrachloro-p-dioxin (TCDD) is the most toxic, which cause CNS and peripheral nervous system neuropathies. l8l... 

Dioxin, the principal toxic imparity in chlorophenoxy herbicides, has been in nse in chemical warfare to destroy crops and defoliate jungles. It occnrs as an imparity in trace amount in the herbicide 2,4,5-T. It is formed as a by-product in the synthesis of 2,4,5-trichlorophenol. It has been detected in distillation bottom tars from... 

This substance is moderately toxic by oral route. The oral LD50 values published in the literature vary. The LD50 (oral) in rat is with in the range of 700 mg/kg, comparable to that of Silvex. The toxic symptoms are similar to those of other chlorophenoxy acids. Contact with skin or eye can cause irritation. The vapor is irritant to mucous membranes and upper respiratory tract. 

Chlorophenoxy compounds have been widely used as herbicides. Agent Orange was a mixture of the chlorophenoxy herbicides 2,4-D (dichlorophenoxyacetic acid) and 2,4,5-T (trichlorophenoxyacetic acid) that also contained small amounts of the highly toxic contaminant TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin see p 184) derived from the process of manufacturing 2,4,5-T. Manufacture ot 2,4-D by chlorination of phenol does not produce TCDD. Populations involved in manufacture or handling of 2,4,5-T may show elevated levels of TCDD on serum testing and overall increased rates of cancer compared to the general population. 

The measures on this card also apply to 2-(2-methyl 4-chlorophenoxy)propionic acid (MCPP). Solvent contained in commercial products is often more toxic than active substance. ... 

Synonyms 3- [4-(4-Chlorophenoxy) phenyl]-1,1-dimethylurea 3-(p-(p-Chlorophenoxy) phenyl)-1,1-dimethylurea Empirical C15H16CIN2O2 Properties Cryst m.w. 290.77 Toxicology LD50 (oral, rat) 3700 mg/kg, (skin, rat) > 3 g/kg LC50 (inh., rat, 6 h) > 1350 mg/m mod. toxic by ing. mutagen TSCA listed Environmental Nontoxic to fish Precaution EPA extremely hazardous substances list... 

CE has been used for the analysis of chiral pollutants, e.g., pesticides, polynuclear aromatic hydrocarbons, amines, carbonyl compounds, surfactants, dyes, and other toxic compounds. Moreover, CE has also been utilized to separate the structural isomers of various toxic pollutants such as phenols, polyaromatic hydrocarbons, and so on. Sarac, Chankvetadze, and Blaschke " resolved the enantiomers of 2-hydrazino-2-methyl-3-(3,4-dihydroxyphenyl)propanoic acid using CD as the BGE additive. The CDs used were native, neutral, and ionic in nature with phosphate buffer as BGE. Welseloh, Wolf, and Konig investigated the CE method for the separation of biphenyls, using a phosphate buffer as BGE with CD as the chiral additive. Miura et al., used CE for the chiral resolution of seven phenoxy acid herbicides using methylated CDs as the BGE additives. Furthermore, the same group resolved 2-(4-chlorophenoxy) propionic acid (MCPP), 2-(2,4-dichlorophenoxy) propionic acid (DCPP), (2,4-dichlorophenoxy) acetic acid (2,4-D), 2-(4-chlorophenoxy) propionic acid (2,4-CPPA), [(2,4,5-... 

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