Chlormezanone

Condensation of p-chlorobenzaldehyde with 3-mercaptopropionic acid in the presence of ammonium carbonate leads to the thiazi-none, 179. The reaction very probably proceeds by the intermediacy of the carbonyl addition product, I7S lactamization completes formation of the observed product. Oxidation of 179 to the sulfone by means of potassium permanganate in acetic acid gives chlormezanone (180), a minor tranquilizer with muscle-relaxant properties. 

Chlorobenzaldehyde Chlormezanone Chlorobenzene Methixene HCI p-Chlorobenzene sulfonamide Chlorpropamide... 

C7H5CIO 104-88-1) see Baclofen Carbinoxamine Chlormezanone Chloropyrainine Nicoclonatc 2-chlorobenzaIdehydc oxime (C7HSCINO 3717-28-0) see Cloxacillin chlorobenzene... 

Since 1958, chlormezanone was marketed by Sanofi-Winthrop, under the brand name Trancopal, as a centrally acting muscle relaxant in lower back pain [22,23]. Evidence of the efficacy of chlormezanone was, however, limited and of poor quality. In comparison to other centrally acting muscle relaxants in lower back pain, there... 

EMEA Final Opinion of the Committee for Proprietary Medicinal Products Pursuant to Article 12 of Council Directive 75/319/EEC as Amended for Medicinal products Chlormezanone. www.emea.eu.int/pdfs/human/phv/ EN/037597en.pdfi last accessed on 16th December 2003. 

Sanofi, W.P. Discontinuation of Trancopal (chlormezanone). www.fda. gov/Medwatch/safety/trancopa.htm, last accessed on 16th December 2003. Pharmainformation Appetitziigler. www.uibk.ac.at/c/c5/c515/info/info7-4.html, last accessed on 15th December 2002. 

The main human plasma metabolite of chlormezanone (5.75), a muscle relaxant, was found to be the ring-opened compound 5.76. Since hydrolysis... 

Chlormezanone Chlormezanone, 2-(p-chlorophenyl)-tetrahydro-3-methyl-4H-l,3-tiazin-4-on-1,1-dioxide (5.2.8), is synthesized by joint condensation of mercaptopropionic acid, methylamine, and 4-chlorobenzaldehyde, evidently through the intermediate stage of formation of 4-chlorobenzylidenemethylamine, giving the aminothioacetal 2-(p-chlorophenyl)-tetrahydro-3-methyl-4H-l,3-tiazin-4-one (5.2.7). Oxidation of the sulfur atom using potassium permanganate gives chlormezanone (5.2.8) [62,63]. 

Chlormezanone improves the emotional state of the patient, relieving moderate anxiety and stress. However, it has a number of side effects, and because it does not have any advantage over other anxiolytics, it is rarely used in practice. Synonyms of this drag are trancopal, alinam, flexipirin, and others. 

There is a very great demand for drugs for the relief of anxiety. This was formerly met by the use of alcohol, bromides or barbiturates, which carried the risk of abuse or dangerous toxicity. The first of the modern minor tranquilizers, introduced from 1946 onwards, were drugs described as skeletal muscle relaxants. These were mainly derivatives of polyhydric alcohols, but heterocyclic examples included metaxolone (161), which is related to the aryl ethers of glycerol, chlorzoxazone (162) and chlormezanone (163). Dantrolene sodium (164) is a muscle relaxant and CNS depressant. 

Chlorexolone as diuretic, 1, 174 Chlorides synthesis, 1, 448 Chlorin, 4, 370 metal chelates, 4, 391 Chlorin, dihydroxy-, 4, 393 Chlorin e6, 4, 404 trimethyl ester, 4, 398 synthesis, 4, 416 Chlorination pyridazines, 3, 20, 21 Chlorine trifluoride bonding, 1, 564 Chlorin-phlorin, 4, 398 Chlorins, 4, 378 absorption spectra, 4, 389 formation, 4, 394 molecular structure, 4, 385 oxidation, 4, 395 Chlorisondamine chloride as hypertensive agent, 1, 176 Chlormethiazoles metabolism, 1, 235 Chlormethiuron against ectoparasites veterinary use, 1, 217 Chlormezanone as antidepressant, 1, 169 Chlorocruoroheme, 4, 380 Chlorofucin conformation, 7, 703 Chloronium iodide, biphenylene-reactions, 1, 566... 

In addition to the above-discussed parameters, other factors such as dimension of the column, particle size of the silica gel, and mobile phase additives may be considered for the optimization of chiral resolution on these CSPs. Metal ions often are important structural components in some proteins to organize conformation [112]. Therefore, the effect of metal ions as mobile phase additives may be useful. Oda et al. [74] used zinc ions as the mobile phase additive on avidin CSP to improve the chiral resolution of ibuprofen, chlormezanone, and other drugs. The results are summarized in Table 5, which indicates that the addition of zinc ions in the mobile phase has resulted into an improved resolution of some... 

Note PP 2-phenylpropionic acid CM chlormezanone TP trihexylphenidyl hydrochloride CP cloperastine IP ibuprofen. 1 50mM Tris buffer (pH 7)-methanol (90 10, v/v) mobile phase 2 50 mM Tris buffer (pH 7)-methanol (70 30, v/v) mobile phase. 

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