Chlormethiazole. metabolism

Chlorexolone as diuretic, 1, 174 Chlorides synthesis, 1, 448 Chlorin, 4, 370 metal chelates, 4, 391 Chlorin, dihydroxy-, 4, 393 Chlorin e6, 4, 404 trimethyl ester, 4, 398 synthesis, 4, 416 Chlorination pyridazines, 3, 20, 21 Chlorine trifluoride bonding, 1, 564 Chlorin-phlorin, 4, 398 Chlorins, 4, 378 absorption spectra, 4, 389 formation, 4, 394 molecular structure, 4, 385 oxidation, 4, 395 Chlorisondamine chloride as hypertensive agent, 1, 176 Chlormethiazoles metabolism, 1, 235 Chlormethiuron against ectoparasites veterinary use, 1, 217 Chlormezanone as antidepressant, 1, 169 Chlorocruoroheme, 4, 380 Chlorofucin conformation, 7, 703 Chloronium iodide, biphenylene-reactions, 1, 566... [Pg.577]

CHLORMETHIAZOLE H2 RECEPTOR BLOCKERS -CIMETIDINE t efficacy and adverse effects, e.g. sedation, hangover effect Inhibition of metabolism Monitor closely l dose may be required... [Pg.272]

Chlormethiazole is metabolized in the liver at a high rate and is excreted in the urine mainly in the form of inactive metabolites. The proportion of unchanged substance is usually less than 5% of the applied dose. The biological availability therefore increases in patients with impaired liver function. Metabolic deactivation proceeds by stepwise oxidation of the chloroethyl group to 4-methylthiazole-5-acetic acid. Other routes are shown in Fig. 8-36. The main metabolites in urine are the 1- and 2-hydroxyethyl derivatives. Some metabolites are excreted as conjugates [44],... [Pg.151]

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