Contact dermatitis chlorhexidine

Osmundsen PE. Contact dermatitis to chlorhexidine. Contact Dermatitis 1982 8(2) 81-3. 

Lasthein Andersen B, Brandrup F. Contact dermatitis from chlorhexidine. Contact Dermatitis 1985 13(5) 307-9. 

Barrazza V. Connubial allergic contact balanitis due to chlorhexidine. Contact Dermatitis 2001 45(1) 42. 

Eighteen cases of an ichthyosiform contact dermatitis caused by antiseptic solutions containing 3% cetrimide and 0.3% chlorhexidine have been reported (5,6). Biopsies showed hyperkeratosis with striking vesicula-tion of lamellar bodies in the granular cells and upper spinous cells, premature secretion of lamellar bodies, and abundant remnants of lamellar bodies and retention of desmosomes between corneocytes. Cetrimide, and not chlorhexidine, was said to be the cause of the dermatitis. 

Following disinfection of a drain insertion site with chlorhexidine digluconate 2% solution, a 43-year-old man had severe anaphylaxis, manifest as dyspnea, shock, and ST segment elevation (46). In the past he had had two episodes of contact dermatitis with chlorhexidine antiseptics. 

Local hypersensitivity reactions to chlorhexidine-impregnated patches occur in neonates (49). In a randomized comparison of povidone-iodine and a chlorhexidine gluconate impregnated dressing for the prevention of central venous catheter infections in neonates, the risk of local contact dermatitis limited the use of the chlorhexidine dressing (50). 

Lauerma AI. Simultaneous immediate and delayed hypersensitivity to chlorhexidine digluconate. Contact Dermatitis 2001 44(1) 59. 

Fischer, L.A., and T. Agner. 2004. Curcumin allergy in relation to yellow chlorhexidine solution used for skin disinfection prior to surgery. Contact Dermat. 51(l) 39-40. 

Hexomedine (Hexamidine), a disinfectant with a structure similar to chlorhexidine, produced allergic contact dermatitis in a female patient. Patch test with chlorhexidine was negative (Van Ketel 1975). 

Wahlberg JE (1971) Sensitization to thioxolone. Contact Dermatitis Newslett 10 222 Wahlberg JE (1976) Routine patch testing with irgasan DP 300. Contact Dermatitis 2 292 Wahlberg JE, Wennersten G (1971) Hypersensitivity and photosensitivity to chlorhexidine. Dermatologica 143 376-379... 

Definition Salt of chlorhexidine and gluconic acid Formuia C22H30CI2N10 2C6H12O7 Properties Sol. > 50% in water m.w. 897.76 Toxicoiogy LD50 (oral, rat) 2 g/kg, (subcut., rat) 3320 mg/kg, (IV, rat) 24,200 pg/kg poison by IV route mod. toxic by ing. and subcut. routes may cause contact dermatitis mutagenic data TSCA listed... 

Susitaival P, Hakkinen L (1989) Anaphylactic allergy to chlorhexidine cream. In Frosch PJ, Dooms-Goossens A, Lachapelle J-M, et al. (eds) Current topics in contact dermatitis. Springer, Berlin Heidelberg New York, pp 99-103... 

Knudsen BB, Avnstorp C (1991) Chlorhexidine gluconate an acetate in patch testing. Contact Dermatitis 24 45-49 Koch P, Bahmer FA, Hausen BM (1995) Allergic contact dermatitis from purified eosin. Contact Dermatitis 32 ... 

Weitz N, Lauren CT, Weiser J, LeBoeuf NR, Grossman ME, Biagas K, et al. Chlorhexidine gluconate-impregnated central access catheter dressings as a cause of erosive contact dermatitis a report of 7 cases. JAMA Dermatol 2013 149(2) 195-9. 

Ebo DG, Stevens WJ, Bridts CH, Matthieu L. Contact allergic dermatitis and hfe-threatemng anaphylaxis to chlorhexidine. J Allergy Chn Immunol 1998 101(1 Pt l) 128-9. 

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