Chloramphenicol ophthalmic solution

While the metastable forms offer higher dissolution rates, many manufacturers use a particular amorphous, crystalline, salt, or ester form of a drug with the solubility needed to be dissolved in the established conditions, for instance, to prepare a chloramphenicol ophthalmic solution [39]. Thus, the selection of amorphous or crystalline form of a drug may be of considerable importance to facilitate the formulation, handling, and stability [37]. 

Surfactants. The use of surfactants is greatly restricted in formulating ophthalmic solutions. The order of surfactant toxicity is anionic > cationic >> nonionic. Several nonionic surfactants are used in relatively low concentrations to aid in dispersing steroids in suspensions and to achieve or to improve solution clarity. Those principally used are the sorbitan ether esters of oleic acid (Polysorbate or Tween 20 and 80), polymers of oxyethylated octyl phenol (Tyloxapol), and polyoxyl 40 stearate. The lowest concentration possible is used to perform the desired function. Their effect on preservative efficacy and their possible binding by macromolecules must be taken into account, as well as their effect on ocular irritation. The use of surfactants as cosolvents for an ophthalmic solution of chloramphenicol has been described [271]. This com-... 

Chloromycetin ophthalmic solution Chloramphenicol Boric Buffer... 

Chloramphenicol (Chloromycetin Ophthalmic) Ciprofloxacin (Cipro) Erythromycin Gentamicin sulfate (Garamycin Ophthalmic) Norfloxacin (Chibroxin) Tobramycin (Nebcin, Tobrex) Natamycin (Natacyn Ophthalmic Idoxuridine (IDU) Trifluridine (Viroptic) Vidarabine monohydrate (Vira-A) Dexamethasone Diclofenac Na (Voltaren) Suprofen Profenal) Ketorolac tromethamine (Acular) Olopatadine HCL Ophthalmic solution Medrysone (HMS Liquifilm) Prednisolone acetate Prednisolone Na phosphate Combination TobraDex... 

Chloramphenicol 1 %, polysorbate 80 6 %, in water for injection has been suggested as an ophthalmic solution [95]. Other formulae have been given and some of these are collected in Table 6.10. A solution of the antibiotic has been prepared in 50% iV,iV-dimethylacetamide as an intravenous injection. N,N-dimethylacetamide is a hydrotropic substance, a group of compounds whose actions are discussed in Section 6.7. Different crystal forms of chloramphenicol palmitate are soluble to differing extents in solutions of polysorbate 60. A detailed study of the solubilization of chloramphenicol in cetomacrogol solutions has been reported by Rogers [98] Regdon-Kiss and Kedvessy [99] have studied the... 

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