Chloral monohydrate

Beilstein Handbook Reference) AI3-00082 Aquachloral Bi 3411 BRN 1698497 Caswell No. 168 CCRIS 4142 Chloradorm Chloral hydrate Chloral monohydrate Chloraldural Chloraldurat Chloralex Chloral Hydras Chloralvan Cohidrate DEA No. 2465 Oormal EINECS 206-117-5 EPA PesScide Chemical Code 268100 Escre Felsules HSDB 222 Hydrate de chloral Hynos Kessodrate Kloralhydrat Knockout drops Lorinal Noctec ... 

A representative set of such structures (7.80-7.86) is shown, all of which result in the formation of aldol adducts with high ee. Replacement of the carboxylic acid moiety with a bioisosteric tetrazole results in a catalyst (7.80) that is both more reactive than L-proline (7.66) and more readily soluble in organic solvents such as THF.38a.b jji a similar vein, acyl sulfonamides such as (7.81) give good enantios-electivities in the aldol reaction with aromatic aldehydes in organic solvents such as dichloromethane and acetone. 3 The addition of stoichiometric amounts of water increases the activity of tetrazole (7.80) further and this allows the use of aldehydes such as chloral monohydrate (7.87) and formaldehyde, which have an affinity for water and are generally poor substrates for the catalytic asymmetric aldol reaction. 38 = Catalysts (7.82)38 (7.33) 3Sd ijpophilic substiments,... 

Mimicking the pyruvate aldol reaction has been a long-standing goal for chemists. In 2005, Dondoni and co-workers reported the dimerization of ethyl pyruvate in the presence of a diamine catalyst [53]. This donor also reacts with chloral monohydrate, giving the desired aldol with both moderate enantioselectivity (86% cc) and yield (55%), most likely due to insufficient reactivity [28c]. Pyruvic aldehyde dimethyl acetal is a decent aldol donor for aromatic as well as aliphatic aldehydes (Chart 3.3)... 

Interesting results were obtained with proHne-tetrazole 22 in the reaction between ketones and chloral monohydrate or anhydrous chloral and water (100mol%). High yields and stereoselectivities were observed (Scheme 24.4). Addition of a higher amount of water increased the enantioselectivity of the reac-hon and decreased the diastereoselechvity. In contrast, the use of a catalytic amount of water (20 or 50mol%) disabled the catalyhc cycle (ca. 5% conversion). 

Monohydric alcohols, aldehydes (including chloral hydrate), ketones, cinnamic acid, amines (2-naphthylaminc is odourless), nitrophenols (resemble both phenol and nitro-compound),... 

Chloral hydrate and chloral alcoholate react with phosphine in the presence of HCi to give compound 4 in the form of its monohydrates The preparation of this compound from chloral hydrate and phosphonium iodide has been previously described by Girard... 

Chloral condensations with aromatic hydrocarbons (and related derivatives) give rise to diaryltrichloroethane compounds, and are brought about in the presence of acid catalysts, proceeding with the formation of carbinol intermediates (Scheme 2.1). Commonly used catalysts include concentrated H2SO4 and its monohydrate, HCl, HF, I O,-, Lewis acids and a series of other acid agents [1, 2]. 

Chloral Hydrate, USP. Chloral hydrate, trichloroacetal-dehyde monohydrate. CCIjCH(OH)2 (Noctec). is an aldehyde hydrate stable enough to be isolated. The relative stability of this gem-dioi is largely due to an unfavorable dipole-dipole repulsion between the trichloromethyl carbon and the carbonyl carbon present in the parent carbonyl compound. ... 

Chloral Hydrate (Chloralis Hydras Chloratum Hydratum) also known as 2,2,2-Trichlor-oethane-1,1-diol and trichloroacetaldehyde monohydrate. 

Trichlorinated isocyanuric acid. See Trichloroisocyanuric acid Trichloroacetaldehyde hydrate Trichloroacetaldehyde, hydrated Trichloroacetaldehyde monohydrate. See Chloral hydrate Trichloroacetic acid... 

Synonyms 2,2,2-Trichloro-l,1-ethanediol trichloroacetaldehyde monohydrate chloral Trade names Aquachloral, Noctec... 

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