Chitosan physical properties

By choosing the excipient type and concentration, and by varying the spray-drying parameters, control was achieved over the physical properties of the dry chitosan powders. The in vitro release of betamethasone showed a dose-dependent burst followed by a slower release phase that was proportional to the drug concentration in the range 14-44% w/w [200]. 

Kang HS, Park SH, Lee YG et al (2007) Polyelectrolyte complex hydrogel composed of chitosan and poly(y-glutamic acid) for biological application Preparation, physical properties, and cytocompatibility. J Appl Polym Sci 103 386-394... 

Chitin and Chitosan Sources, Chemistry, Biochemistry, Biochemistry, Physical Properties and Applications Skjak-Braek, G. Anthousen, T. Sanford, P., Eds. Elsevier Applied Science New York, NY, 1989 835 pp. 

Subramanian, A. and Lin, H. Y. (2005). Crosslinked chitosan Its physical properties and the effects of matrix stiffness on chondrocyte cell morphology and proliferation. ]. Biomed. Mater. Res. 75A, 742-753. 

Santos Veiga F, Pina M. et al. Physical properties of chitosan pellets produced by extnision-spheronization influence of formulation variables. Int J Pharm 2002 246 153-69-... 

Ishikawa K, Ducheyne P, Radin S (1993) Determination of the Ca/P ratio in calcium-deficient hydroxylapatite using X-ray diffraction analysis. J Mater Sci Mater in Med 4 165-168 Ishikawa K, Miyamoto Y, Kon M, Nagayama M, Asaoka K (1995) Non-decay type fast-setting calcium phosphate cement composite with sodium alginate. Biomaterials 16 527-532 Itatani K, Iwafune K, Howell FS, Aizawa M (2000) Preparation of various calcium-phosphate powders by ultrasonic spray freeze-drying technique. Mater Res Bull 35 574-85 Ito M, Hidaka Y, Nakajima M, Yagasaki H, Kafrawy AH (1999) Effect of hydroxylapatite content on physical properties and coimective tissue reactions to a chitosan-hydroxylapatite composite membrane. J Biomed Mater Res 45 204-208... 

Sanchez-Gonzalez, L., Chafer, M., Chiralt, A., Gonzalez-Martinez, C. 2010a. Physical properties of edible chitosan films containing bergamot essential oil and their inhibitory action on Penicillium italicum. Carbohydrate Polymers, 82 277-283. 

Vasconez, M.B., Flores, S.K., Campos, C.A., Alvarado, J., Gerschenson, L.N. 2009. Antimicrobial activity and physical properties of chitosan-tapioca starch based edible films and coatings. Food Research International, 42(7) 762-769. 

Physical properties [electrokinetic properties and colloidal stability] of nanoparticles formed by chitosan ionically cross-linked by sodium tripolyphosphate have been studied by L6pez-Le6n et al. [46] as a function of pH and ionic strength of the medium. They observed that due to glucosamine groups, change of pH from acid to... 

Kim, S. K., and Rha, C. (1989). Transdermal permeation of proteins in chitosan capsules Eds. Chitin and Chitosan-Sources Chemistry, Physical Properties and Application, Elsevier London, 365. 

The chitosan receives a widespread utilization in pharmaceutical, medical, biotechnology, cosmetics, food, agriculture, paper, and textile Industries due to its biodegradability, biocompatibility, antibacterial activity, nontoxicity, and versatile chemical and physical properties (Rinaudo, 2008 Dodane and Vilivalam, 1998 Mourya and Inamdar, 2008 Jayakumar et al., 2007 Hirano, 1999 Dash et al., 2011 Prabaharan, 2008 Ilium, 1998). 

The major advantage in preparation of PUs is that they can be synthesized from various types of polymers that contain different mechanical and physical properties. In particular, poly(ester-urethane) elastomers are interesting because they can be designed synthetically to have hydroxyl functional groups at their chain terminals. These react readily with diisocyanate groups to form urethane linkages. In the same sense, chemical modification of the involved monomers allows incorporation of some functionality into a PU matrix, thus Improving a specific property. An example of chemical modification of monomers was developed with chitosan. This polysaccharide is product of the alkaline deacetylation of... 

In this chapter, we first discuss the chemical and physical properties of chitosan, including the synthesis, modification, molecular structure, characterization, and structure-property relationship. Second, we review the topics of biocompatibility, biodegradability, and antimicrobial activity of chitosan. These properties make chitosan a potential biomaterial for many biomedical applications. 

A. Wang, Q. Ao, Y. Wei, K. Gong, X. Liu, N. Zhao, et al.. Physical properties and biocompatibility of a porous chitosan-based fiber-reinforced conduit for nerve regeneration, Biotechnol. Lett. 29 (2007) 1697-1702. 

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