Chitosan-based hydrogels

Han, H. D., Song, C. K., Park, Y. S. et al. 2007. A chitosan hydrogel-based cancer drug dehvery system exhibits synergistic antitumor effects by combining with a vaccinia viral vaccine. Int. J. Pharm., 350 27-34. 

Investigations on biocompatible hydrogels based exclusively on polysaccharide chains were reported chitosan was linked with dialdehyde obtained from scleroglucan by controlled periodate oxidation [218]. The reaction took... 

Wu J, Wei W, Wang LY, Su ZG, Ma GH (2007) A thermosensitive hydrogel based on quatemized chitosan and polyethylene glycol) for nasal drug delivery system. Biomaterials 28 2220-2232. 

Recently, other approaches and modifications of HA for gene delivery applications have been investigated. Among the most interesting ones are mixed chitosan-hyaluronan based gene delivery systems [68-70] and PEG-HA photocrosslinked hydrogels [71]. HA has also been used to improve the biocompatibility of branched PEI via covalent conjugation [72],... 

Polyacrylamide is used in a wide range of cosmetic products such as moisturizers, lotions, creams, self-tanning products, etc. Polyacrylamides were first used as an implantable carrier for sustained delivery of insulin to lengthen the life of diabetic rats. Since then, various drug delivery systems based on polyacrylamide have been developed. It is also used as a carrier for other bioactive macromolecules and cells to produce the desired effects. Polyacrylamide-chitosan hydrogels are biocompatible and are used for sustained antibiotic release. Polyacrylamide is also used in extra corporeal toxin-removing devices, which remove unwanted toxic substances and subsequently returns the detoxified component to the circulation effectively. The function of polyacrylamide in an extracorporeal toxin removal modality is to provide a support matrix for immobilization of the functional parts or ligands. 

Yang, J., Chen, J., Pan, D., Wan, Y, and Wang, Z., pH-sensitive interpenetrating network hydrogels based on chitosan derivatives and alginate for oral drug delivery, Carbohvdr. Polvm.. 92 (01)(2013), 719-725. 

X. Chen, W. Li, W. Zhong, Y. Lu, T. Yu, pH sensitivity and ion sensitivity of hydrogels based on complex-forming chitosan/silk fibroin interpenetrating polymer network, J. Appl. Polym. Sci. 65 (11) (1997) 2257-2262. 

Zhao et al. prepared antibacterial hydrogels based on PVA and carboxy-methylated chitosan (CM-chitosan) with e-beam irradiation. PVA was cross-linkable under irradiation, but this polymer had no antibacterial activity. A hydrogel based on 10 wt% of PVA and not more than 3 wt% of CM-chitosan showed an antibacterial activity against Escherichia coli. 

Schuetz, YB Gumy, R Jordan, 0. A Novel Thermoresponsive Hydrogel Based on Chitosan. CwJPharm Biopharm, 2008, 68, 19-25. 

Gamica-Palafox, I.M., Sanchez-Arevalo, F.M., Velasquillo, C., Garcia-Carvajal, Z.Y, Garcia-Lopez, J, Ortega-Sanchez, C. et al (2014) Mechanical and structural response of a hybrid hydrogel based on chitosan and poly(vinyl alcohol) cross-linked with epichlorohydrin for potential use in tissue engineering. 

Cheng YH, et al. Sustained delivery of latanoprost by thermosensitive chitosan-gelatin-based hydrogel for controlling ocular hypertension. Acta Biomater 2014 10(10) 4360-6. 

Journal of Materials Science Materials in Medicine 10, No.5, May 1999, p.301-7 HYDROGELS BASED ON CHITOSAN AND DEXTRAN AS POTENTIAL DRUG DELIVERY SYSTEMS... 

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