Receptor chemokine

Models also can assist in experimental design and the determination of the limits of experimental systems. For example, it is known that three proteins mediate the interaction of HIV with cells namely, the chemokine receptor CCR5, the cellular protein CD4, and the viral coat protein gpl20. An extremely useful experimental system to study this interaction is one in which radioactive CD4, prebound to soluble gpl20, is allowed to bind to cellular receptor CCR5. This system can be used to screen for... 

Cagnon, L., and Rossi, J. J. (2000). Down regulation of the CCRS beta-chemokine receptor and inhibition of HIV-1 infection by stable VAl-ribozyme chimeric transcripts. Antisen. Nuc. A. Drug Dev. 10 251—261. 

Mellado, M., Rodriguez-Frade, J. M., Vila-Coro, A. J., Fernandez, S., MartindeAna, A., Jones, D. R., Toran, J. L., and Mardnez-Aet, C. (2001). Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO J. 20 2497-2507. 

Central tendency, 226-227 Chemical genomics, 178 Chemical tools, in target-based drug discovery, 178-179 Chemokine C receptor type 1, 133 Chemokine receptors, 6, 44, 53, 129, 132, 177... 

G-protein-coupled Receptors Dopamine System Adenosine Receptors Chemokine Receptors... 

T-cells, representing the adaptive arm of the immune response, also play a critical role in atherogenesis, and enter lesions in response to the chemokines inducible protein-10 (DP-10), monokine induced by DFN-y (MIG), and DFN-inducible T-cell a-chemoattractant (I-TAC), which bind CXCR3 (a chemokine receptor containing two cysteine residues separated by one amino acid), highly expressed by T lymphocytes in the plaque. The... 

CC, and one CX3C and XC chemokine receptors have been cloned so far [2]. Receptor binding initiates a cascade of intracellular events mediated by the receptor-associated heterotrimeric G-proteins. These G-protein subunits trigger various effector enzymes that lead to the activation not only of chemotaxis but also to a wide range of fimctions in different leukocytes such as an increase in the respiratory burst, degranulation, phagocytosis, and lipid mediator synthesis. 

Chemokines have been shown to be associated with a number of autoinflammatory diseases including multiple sclerosis, rheumatoid arthritis, atherosclerosis, dermatitis, and organ transplant rejection. Evidence, reviewed below, is mounting that chemokines may play a major role in the pathophysiology of these diseases and thus chemokine receptor antagonists could prove to be useful therapeutics in treating these and other proinflammatory diseases. 

Although leukocytes continue to be the major site of expression of chemokine receptors, several studies have recently demonstrated chemokine receptor expression on neurons in the CNS. 

Chemokine Receptors. Figure 1 Biological functions of chemokine receptors as exemplified by the chemokine receptor CXCR4. 

A number of viruses, including those in the Heipes and Pox families, express chemokine-like or chemokine receptor-like molecules that presumably help them to... 

Chemokine Receptors. Table 1 Chemokine receptor antagonists in clinical trial... 

Ribeiro S, Homk R (2005) Chemokine receptor antagonists from the bench to tire clinic. Weinheim, Wiley-VCH, pp 371-402... 

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