Chemical target identification

Bombs for Aircroft(Aerial Bombs). An aerial bomb is a type of ammo designed to be dropped from an aircraft in flight to inflict damage on the enemy or to serve a special purpose such as target identification or provision of a light source for photography A bomb consists usually of a metal container filled with expls or chemicals, a device for stabilizing... 

Kwon, H. J. (2003). Chemical genomics-based target identification and validation of anti-angiogenic agents. Current Medicinal Chemistry 10, 717-736. 

The evaluation of different chemicals involves identification of potential active agents and the mechanisms by which they present their toxic effect, prediction of effective pharmaceutical cytotoxicity for treatment of patients with cancer, evaluation of the activity range of the studied compound, identification of a target cell population and of the toxic concentration range, and the relation between pharmaceutical concentration and exposure period to reach a desired activity. The chosen assay system should provide a reproducible dose-response curve with low variability over a concentration range that includes in vivo exposure. In addition, the selected response criterion should present a linear relationship with cell number, and the information obtained with a dose-response curve should be related to the in vivo effect of the same active agent or drug. 

Whole cell growth inhibition screens combined with subsequent target identification using molecular methods have proven viable approaches to the discovery of novel antibacterial inhibitors. Andries and colleagues (2005) at Johnson Johnson employed whole cell assays to discover a series of antimycobacterial diarylquinolines (DARQs). Chemical optimization of a lead compound led to DARQ derivatives exhibiting potent in vitro activities against several mycobacteria including Mycobacterium tuberculosis (Andries et al., 2005 Ji et al., 2006), with MICs below 0.5 pg/mL. Antimycobacterial efficacy in vivo was confirmed for three of the derivatives. 

Chemical Genetics - How Chemistry Can Contribute to Target Identification and Validation... 

Focus within the pharmaceutical industry has been to increase the likelihood of successfully developing clinical candidates by optimizing the components of the discovery process (i.e., spanning target identification chemical... 

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