Chemical Markers for Protein-Based Identification or Biodetection

5 CHEMICAL MARKERS FOR PROTEIN-BASED IDENTIFICATION OR BIODETECTION 

This result is important to fully understanding the biochemical and ultra-structural origin of peaks and the physiological basis for variation. It not only helps in designing the analytical strategy (e.g., in selection of cleanup columns) but, more important, in making a decision on whether the marker should be used for strain or species identification or for biodetection. For example, there are a number of low-molecular weight peptides (1500-8000 kDa) present in 

Analysis of bacterial monomers is performed routinely to detect bacteria at trace levels in environmental samples using GC-MS-MS. PCR is also used routinely by the molecular biology community for detection of clinical infections. MS and MS-MS greatly improve the specificity of analysis of PCR products and provide additional structural information that may be important in apply- 

Morgan, S. L. Larsson, L. Odham, G. (Eds.). Analytical Microbiology Methods Chromatography and Mass Spectrometry. New York Plenum, 1990. 

Fenselau, C. (Ed.). Mass Spectrometry for the Characterization of Microorganisms. Washington, DC American Chemical Society, 1994. 

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