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Chemical development pharmaceuticals

References List of important reports/sections Partner reports (chemical development, pharmaceutics, etc.)... [Pg.496]

Bioprocess plants are an essential part of food, fine chemical and pharmaceutical industries. Use of microorganisms to transform biological materials for production of fermented foods, cheese and chemicals has its antiquity. Bioprocesses have been developed for an enoimous range of commercial products, as listed in Table 1.1. Most of the products originate from relatively cheap raw materials. Production of industrial alcohols and organic solvents is mostly originated from cheap feed stocks. The more expensive and special bioprocesses are in the production of antibiotics, monoclonal antibodies and vaccines. Industrial enzymes and living cells such as baker s yeast and brewer s yeast are also commercial products obtained from bioprocess plants. [Pg.4]

Transient reactors, such as pulse (chromatographic) reactors, temporary analysis of products (TAP) reactors, multitrack reactors, and temperature-programmed reactors have been developed mainly to study gas-solid (catalyst) reactions. These are rather sophisticated techniques used to study mechanisms of catalytic processes at the molecular level in great detail. Since this is rarely done in the development of processes for the manufacture of fine chemicals and pharmaceuticals, these reactors are not discussed further. The interested reader is referred to works by Anderson and Pratt (1985) and Kapteijn and Moulijn (1997). [Pg.295]

A discovery group transferred the synthesis of RWJ-26240 (Figure 7)174 to the Chemical Development Department (R. W. Johnson Pharmaceutical... [Pg.172]

Chemical Development Department The R. W. Johnson Pharmaceutical Research Insitute Spring House, Pennsylvania... [Pg.477]

Zhu, C. Chen, T.-M. Hwang, K., A comparative study of parallel artificial membrane permeability assay for passive absorption screening, in CPS A2000 The Symposium on Chemical and Pharmaceutical Structure Analysis. Milestone Development Services. Princeton, NJ, Sept. 26-28, 2000. [Pg.281]

The chemical and physical stability of aqueous and nonaqueous suspensions of a number of solvatomorphs of niclosamide has been evaluated in an effort to develop pharmaceutically acceptable suspension formulations [90]. Studied in this work was the anhydrate, two polymorphic monohydrates, the 1 1, Y, A"-dimethyI I ormam ide solvatomorph, the 1 1 dimethyl sulfoxide solvatomorph, the 1 1 methanol solvato-morph, and the 2 1 tetraethylene glycol hemisolvate. All of the solvatomorphs were found to convert initially to one of the polymorphic monohydrates, and over time converted to the more stable monohydrate phase. The various solvatomorphs could be readily desolvated into isomorphic desolvates, but these were unstable and became re-hydrated or re-solvated upon exposure to the appropriate solvent. [Pg.275]

Economic and safety considerations encourage minimal stockpiling of chemicals and avoiding transportation of hazardous substances. These increasing demands offer many opportunities for microwave chemistry in the development of environmentally benign methods for the preparation of intermediates, specialty chemicals and pharmaceuticals [6[. It appears likely that within the next few years, individual chemical reactors will be required for diverse tasks and will need to be easily relocated... [Pg.57]

Renken 2005 Hessel et al. 2005a, b Golb and Hessel 2004 Kockmann et al. 2006). Here, some concepts and recent developments relevant to synthetic chemists will be summarized. Microreactor technology is beginning to be used in the fine chemical and pharmaceutical industries (Hessel et al. 2005b), and several success stories have been reported already (Thayer 2005 Rouhi 2004). [Pg.5]

The latter session included government perspectives from the EPA OPPTS, the EPA Office of Research and Development, the EPA Office of Children s Health Protection, the OECD, the EMEA and the Committee for Medicinal Products for Human Use (CHMP), in addition to industry perspectives reflecting both the chemical and pharmaceutical industries.19 The NIEHS/NIOSH workshop was limited to 23 invited participants. A limited number of background scientific presentations were given, and the emphasis was on break-out group sessions in which a series of predetermined questions were raised and key points were captured by rapporteurs.17... [Pg.351]

Raman spectroscopy is emerging as a powerful analytical tool in the pharmaceutical industry, both in PAT and in qualitative and quantitative analyses of pharmaceuticals. Reviews of analyses of pharmaceuticals by Raman spectroscopy have been published.158 159 Applications include identification of raw materials, quantification of APIs in different formulations, polymorphic screening, and support of chemical development process scale-up. Recently published applications of Raman spectroscopy in high-throughput pharmaceutical analyses include determination of APIs in pharmaceutical liquids,160,161 suspensions,162 163 ointments,164 gel and patch formulations,165 and tablets and capsules.166-172... [Pg.268]


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See also in sourсe #XX -- [ Pg.151 , Pg.152 , Pg.153 , Pg.157 ]




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