Chelating agents sodium edetate

Oxidation, in oral liquids, in practice is inhibited by removal of oxygen from water by boiling, reduction of headspace by completely filling of bottles, addition of a chelating agent (sodium edetate) for the removal of catalysing traces of metals and the addition of antioxidants, such as ascorbic acid (see Sect. 22.2.2). 

Disodium edetate Chelating agent Sodium saccharin Sweetening agent... 

Some strains of P. aeruginosa are resistant to benzalkonium chloride and, in fact, can be grown in solutions concentrated in this agent. This has caused great concern because of the virulent nature of this organism in ocular infections, as discussed previously. Thus, it was an important finding in 1958 that the acquired resistance could be eliminated by the presence of ethylenediaminetetracetic acid (sodium edetate) in the formulation. This action of EDTA has been correlated with its ability to chelate divalent cations, and it is commonly used as a preservative aid [125]. The use of disodium EDTA, where compatible, is recommended in concentrations up to 0.1%. 

The treatment of lead poisoning involves the use of chelating agents to remove the lead from the soft tissues of the body. Thus, agents such as sodium calcium edetate may be used. 

Comments used in pharmaceutical formulations as a chelating agent in concentrations between 0.01-0.1% w/v. Usually edetate calcium disodium is used in pharmaceutical formulations in preference to disodium edetate or sodium edetate to prevent calcium depletion occurring in the body. In food products, edetate calcium disodium may also be used in flavors and as a color retention agent. Edetate calcium disodium occurs as the dihydrate, trihydrate, and anhydrous material. 

Edetate sodium/ Edetate disodium Airet, Alupent, Atrovent Chelating agent 0.02%/0.03%... 

Preservatives Antimicrobial Benzalkonium chloride Benzyl alcohol Chlorhexidine Imidazolidinyl urea Phenol Potassium sorbate 1 Benzoic acid Bronopol Chlorocresol Paraben esters Phenoxyethanol Sorbic acid Antioxidants a-Tocopherol Ascorbic acid Ascorbyl palmitate Butylated hydroxyanisole Butylated hydroxytoluene Sodium ascorbate Sodium metabisulphite Chelating agents Citric acid Edetic acid... 

EDTA, its sodium salt (edetate disodium, Na2EDTA), and a number of closely related compounds chelate many divalent and trivalent metals. The cation used to make a water-soluble salt of EDTA has an important role in the toxicity of the chelator. Na2EDTA causes hypocalcemic tetany. However, edetate calcium disodium (CaNa2EDTA) can be used for treatment of poisoning by metals that have higher affinity for the chelating agent than does Ca. ... 

A number of natural substances, including sodium citrate and ascorbic acid, chelate Pb. Commonly used chelating agents include calcium disodium edetate (CaEDTA), dimercaprol (BAL), 2,2-dimethylcysteine (D-peniciUamine) and 2,3-dimercaptosuc-cinic acid (DMS). Chisholm and Coffin et al." have outlined the appropriate protocols for chelation therapy for children wdth Pb poisoning, whereas Friedheim et al. and the Center for Disease Control, outline the treatment of adult Pb intoxication. 

Di-Na monO Ca salt [62-33-9]. Sodium calcium edetate, BAN, INN. Edetate calcium disodium, USAN. Edathamil calcium disodium. Calcium disodium versenate. Mosatil. Antallin. Ledclair. Other proprietary names Powerful chelating agent used for treatment of lead poisoning. Powder. Forms a tetrahydrate. 

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