Cephalosporins surgical infections

It is a broad spectrum cephalosporin having a long half life and administered once daily and indicated in meningitis, septicaemia, typhoid, urinary tract infections, prophylaxis in surgical infections, pneumonia, STD, bacteremia and pelvic inflammatory disease. 

It is a semisynthetic potent cephalosporin for parenteral administration. It can be administered less frequently because of its long half life. It is used in infections of genitourinary tract, bone, joint and soft tissue infections, septicaemia, endocarditis, gonorrhoea, postoperative chest infections, biliary tract infection and surgical prophylaxis. 

Cefmetazole, a second-generation cephalosporin antibiotic (1 to 8 g IV total dose divided q. 6 to 12 hours), is indicated in the treatment of serious respiratory, urinary, skin and soft-tissue, abdominal, and pelvic infections caused by susceptible organisms. It is also used as surgical prophylaxis. 

Gram Positives Nafcillin (IV) and dicloxacillin (PO) provide excellent coverage of most gram positives and is not destroyed by penicillinases. First generation cephalosporins (e.g., cephalexin, cephazolin) are effective against skin-borne infections in surgical patients. 

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