Cellular resting potential

An Improved Theory of Cellular Resting Potential Incorporating Cooperative Interaction among Surface Anionic Sites... 

Equation (3) was derived on the assumption that the surface anionic sites show no cooperative interaction. In 1979 I published a short article describing a new equation for the cellular resting potential/ incorporating the concept of site-to-site cooperative interaction of the cell surface sites as we have argued for and provided experimental evidence in support for the bulk phase (adsorbed)... 

K Channels belong to a class of membrane proteins that form highly K-selective pores in membranes. All known K Channels are composed of several (usually four) pore forming alpha subunits and auxiliary beta subunits. K Channels play an essential role in cellular excitability, being involved in repolarization of Action Potentials and setting the cell resting potential as well as contributing to potassium homeostasis. 

Kv-channels are closed in the resting state. Upon depolarization of the cellular membrane potential, closed Kv-channels undergo a series of voltage-dependent activating steps until they reach an activated state from which they can open and close in a voltage-independent manner. 

Marine toxins modify the functions of many different types of ion channels in animal cell membranes. These channels may be important for maintaining the cell s resting potential, for generating electrical membrane signals, such as impulses, and for controlling hormonally triggered or metabolic responses. Thus toxins may depolarize membranes, leading to a (sometimes transient) increase in cellular activities, or they may... 

Investigations of the cellular effects of radiofrequency radiation provide evidence of damage to various types of avian and mammalian cells. These effects involve radiofrequency interactions with cell membranes, especially the plasma membrane. Effects include alterations in membrane cation transport, Na+/K+-ATPase activity, protein kinase activity, neutrophil precursor membrane receptors, firing rates and resting potentials of neurons, brain cell metabolism, DNA and RNA synthesis in glioma cells, and mitogenic effects on human lymphocytes (Cleary 1990). 

G. N. Ling, The Cellular Resting and Action Potentials Interpretation Based on the Association-Induction Hypothesis, Physiol. Ghent. Phys. 14, 47 (1982). 

Ionic concentration gradients across membranes serve a variety of functions in cellular activity such as maintainance of resting potential, transmission of nerve impulse, driving cotransport, and secretion or activation of enzymes, hormones and other substances. Thus, studies of the kinetics and mechanism of ion transport across membranes are essential for the understanding of many physiological processes. 

Zorokina, Z.A., Relationship between the Intra- and Extra-Cellular pH, the Rest Potential, and Concentration of Potassium in the Transversostriated Muscular Fiber of the Frog, Cytologia, 3, 49-59 (1961). 

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