Cell surface carbohydrates, in development

Role of Cell Surface Carbohydrates in Development and Disease... 

Kobata, A. and Takasaki, S. (1992). Structure and biosynthesis of cell surface carbohydrates. In Cell Surface Carbohydrates and Cell Development. M.Fukuda, ed. (London CRC Press), pp. 1 24. 

Carbohydrates play important roles in recognition of substances on the cell surface and in transduction of signals. Carbohydrates are involved closely in various diseases such as infection and cancer. For these reasons, increasing efforts have been made to conduct research for dmg development, focusing on carbohydrates in the biological body. This section will outline development of new medicines targeting carbohydrates. In addition, recent advances in... 

Fukuda M (1992) In Fukuda M (ed) Cell surface carbohydrates and cell development. CRC Press, Boca Raton, p 127... 

Sharon, N., and H. Lis. Carbohydrates in Cell Recognition. Sd. Amer. 268 (1), 82-89 (1993). [The development of drugs to stop infection and inflammation by targeting cell-surface carbohydrates.]... 

Gene knockout experiments in mice clearly indicate that cell surface carbohydrates play many vital roles in development and health. Evidence suggests that cell surface carbohydrates function in many cellular activities by interacting with their microenvironment in vivo. Future studies should identify mechanisms underlying activation of cells by cell surface carbohydrates, which are vital for understanding the activities of malignant cancer cells. 

Glycoconjugates are the most functionally and structurally diverse compounds in Nature and it is now well established that protein- and lipid-bound saccharides play essential roles in many molecular processes impacting eukaryotic biology and disease.Examples of such processes include fertilization, embiyogenesis, neuronal development, hormone activities, the proliferation of cells and their organization into specific tissues. Remarkable changes in the cell-surface carbohydrates occur with tumor progression, which... 

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