Carbohydrates, targeting

Publica- Peptide Protein Carbohydrate target Refs. 

Roy R (1996) Sialoside mimetics and conjugates as antiinflammatory agents and inhibitors of flu virus infections.In Witczak ZJ (ed) Carbohydrates targets for drug design. Marcel Dekker, New York, p 84... 

Since neither the chemical nor the enzymatic synthesis alone can assist in the rational design of a new generation of therapeutic carbohydrate target structures, the chemoenzymatic approaches have been successfully utilized [40-42]. 

Lectins can be divided into classes on the basis of their amino acid sequences and biochemical properties. One large class is the C type (for calcium-requiring) found in animals. These proteins each have a homologous domain of 120 amino acids that is responsible for carbohydrate binding. The structure of one such domain bound to a carbohydrate target is shown in Figure 11.26. 

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