Cell proliferation positional data

Also see color figure.) Complex of MHC class I proteins, HTLV-1 peptide (antigen) and TcR. The MHC class I proteins bind and present peptides that are synthesized inside the infected cell to T-cell receptors (TcRs) specific for the bound peptides. Interaction and stimulation of T-cell proliferation occurs with CDS positive, cytotoxic Tc cells. The figure is derived from the coordinates published in the Protein Data Bank file 1BD2. 

PPARa ligands do not induce cell proliferation or suppress apoptosis in human hepatocytes in vitro (Goll et al. 1999 Hasmall et al. 1999 Perrone et al. 1998 Williams and Perrone 1996). Many of these studies included a positive control to ensure that human hepatocytes were of sufficient quality to mount a positive growth response. In comparison, rat or mouse primary hepatocytes exposed to PPARa activators exhibit up to 8-fold induction in cell proliferation (summarized in (Klaunig et al. 2003)). There are no data on human hepatocyte proliferation in vivo, although in vivo and in vitro data from nonhuman primates show cell proliferation is not induced by PPARa activators [Table 17.3 and reviewed in Doull et al. (1999)]. In summary, available data suggest that PPARa activators are unlikely to alter apoptosis and proliferation in human hepatocytes. 

Up to 5% of unstimulated CB mononuclear cells are CSF-1-receptor positive as measured by flow cytometry (data not shown). In the first week of coculture on transduced MMCF cells all CSF-1 isoforms promoted proliferation of CB CD34+ cells with comparable rates (Fig. 5a). However, within four weeks the stimulatory activity of wildtype CSF-1 declined dramatically. Obviously, the soluble isoform provided only a limited expansion of CB CD34+ cells. 

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