Cell Monro

Camptothecin was discovered as an active anticancer drug isolated from the bark of Camptotheca acuminata. The anticancer activity of camptothecin was discovered in the 1960s by the National Cancer Institute (NCI) as part of a systematic effort to screen for novel anticancer agents derived from natural products. Monroe Wall and Mansuhk Wani identified the chemical structure of camptothecin. They also identified the chemical structure of taxol, again under the auspices of the NCI. Susan Hoiwitz was contracted by the NCI to elucidate the anticancer mechanisms of camptothecin. She found in the early 1970s that camptothecin induced DNA breaks and attested DNA and RNA synthesis. However, it is approximately 12 years later, only after DNA topo-isomerase I (Topi) had been identified in human cells, that Leroy Liu and his coworkers found that Topi was the cellular target of camptothecin [reviewed in [1]. 

Fig. 8. — Partial Model of Primary Cell-Wall in Lupin Hypocotyl, Proposed by Monro and Coworkers.49 [The half of the Figure labeled (A) represents the extensin-hemicellulose network, and the half labeled (B) represents the separate, pectic network, which is believed not to involve the wall glycoprotein (extensin). Thus, the cellulose microfibrils (M) are separately cross-linked by two networks of polymers, the first (A) being composed of the wall glycoprotein and polysaccharide (probably hemicelluloses), and the second (B) being composed of the pectic polymers. These two networks have been separated in the Figure for clarity. This model is tentative and incomplete, as the nature of the linkages between the polymers in these two networks has not yet been identified. The...

Hoffman M, Monroe DM III. A cell-based model of hemostasis, Thromb Haemost 2001 85 958-965. 

Ramaswamy S. B., Shu S., Monroe W. A. and Mbata G. N. (1995) Ultrastructure and potential role of integumentary glandular cells in adult male and female Callosobruchus subinnotatus (Pic) and C. maculatus (Fabricius) (Coleoptera Bruchidae). Int. J. Insect Morphol. Embryol. 24, 51-61. 

Mokri B (2001) The Monro-Kellie hypothesis applications in CSF volume depletion. Neurology 56 1746-1748 Naruse S, Horikawa Y, Tanaka C, Hirakawa K, Nishikawa H, Yoshizaki K (1982) Proton nuclear magnetic resonance studies on brain edema. J Neurosurg 56 747-752 Nedergaard M, Vorstrup S, Astrup J (1986) Cell density in the borderzone around old small human brain infarcts. Stroke 17 1129-1137... 

Monroe, J. J., and Tashjian, A.H., Jr. 1995. Actions of palytoxin on Na+ and Ca2+ homeostasis in human osteoblast-like Saos-2 cells. AmJ Physiol 269, C582-589. 

Monroe C, Swann W, Robinson H and Wieman C 1990 Very cold trapped atoms in a vapor cell Phys.Rev.Lett. 65 1571-4... 

The most enthusiastic reports concern the diterpenoids paclitaxel, Taxol (from Taxus brevifolia) and docetaxel, Taxotere (from Taxus baccata) having unique tri- or tetracyclic 20 carbon skeletons extracted from the bark of yew. This tree was known as a toxic plant for animals and humans for centuries. Monroe E. Wall and Mansukh C. Wani, at the Research Triangle Park (Chapel Hill, USA), identified the active principle of the yew tree in 1971. In 1979, Susan Horwitz of the Department of Molecular Pharmacology, Albert Einstein College of Medicine (New York) suggested that paclitaxel s mechanism of action was different from that of any previously known cytotoxic agent. She observed an increase in the mitotic index of P388 cells and an inhibition of human HeLa and mouse fibroblast cells in the G2 and M phases of the cell cycle. 

Monroe N (2011) Increasing the efficiency of a hybrid polymer photovoltaic cell with polymer nanofiber complexes of varied thickness. Young Sci J 8 26-32... 

Monroe, C., Swann, W., Robinson, H., and Wieman, C. E. (1990). Very cold trapped atoms in a vapor cell. Physical Review Letters, 65, 1571—1574. 

C. Monroe, W. Swann, H. Robinson, C. Wieman Very cold trapped atoms in a vapor cell. Phys. Rev. Lett. 65, 1571 (1990)... 

Monro, J. A., D. Penny, and R. W. Bailey The Organization and Growth of Primary Cell Walls of Lupin Hypocotyl. Phytochem. 15, 1193 (1976). 

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