Cell line human oral epidermoid

Fig. 3 Relationship between ATP depletion and Pgp expression levels in various cells. The studies included human breast carcinoma cells, MCF-7, and their MDR subline, MCF-7/ADR human oral epidermoid carcinoma cells, KB, and their MDR subline, KBv wUd-type porcine kidney epithelial cells, LLC-PKl, and human MDRl-transfected cells, LLC-MDRl human umbilical vein endothelial cells, HUVEC bovine brain microvessel endothelial cells, BBMEC and murine myoblast cells, C2C12. EC50 values for each of the cell lines were determined from the dose response curves as the concentration of Plutonic P85 inducing a 50% decrease in intracellular ATP following 2 h exposure of the cells to the block copolymer. The drug efflux transport proteins were identified using the im-munoblot technique and normalized to constitutively expressed y3-actin. Plotted using data reported in [33]...

Antitubercular and antimalarial activity-guided study of the roots of Artocarpus altilis led to the isolation of nine prenylated flavones. Cycloartocarpin (1), Artocarpin (2), and Chaplashin (3) were isolated from the CH2CI2 extract of the root stems, whereas Morusin (4), Cudraflavone (5), Cycloartobiloxanthone (6), Artonin (7), Cudraflavone (8) and Artobiloxanthone (9) were found in the root barks. The isolated compoimds exhibited antitubercular and antiplasmodial activities, and also showed moderate cytotoxicity against KB (human oral epidermoid carcinoma) and BC (human breast cancer) cell lines [33-34]. 

In vitro cytotoxicity of Ik and II was examined using L1210 and KB (human oral epidermoid carcinoma) cells. Compound Ik was inactive up to 100 pg/mL, while II was a potent inhibitor of growth of both cell lines with ICso s of 3.2 and 2.0 pgAnL, respectively. These differences might be a reflection of susceptibility to deoxycytidine kinase. Although the cytotoxicity of II was about 10 times less than that of CNDAC, we plan to compare its activity with other active nucleosides and examine its in vivo activity. 

In the series of the IV-methyl-2,2,-bisimidazole (MBI) complexes R2SnX2 (MBI)130 (R = Me, Et, Bu, Ph X = Cl, Br) the butyl derivatives were the most active against KB (oral epidermoid human carcinoma) cell line. The nature of the halogen bound to the metal atom does not seem to have any influence on activity, except for the butyl complexes, for which the chloride is much more active (ID50 = 0.023 pgml-1), than bromide (ID50 = 0.170 pgml-1). 

Pinus densifiora Sieb. et Zucc. (Pinaceae) EO inhibited proliferation and induced apoptosis in YD 8 cells (human oral squamous carcinoma). Cell proliferation was inhibited by 30% and 60% at concentrations of 40 and 60 pg/mL EO. The EO reduced cancer cells by 70% when treated with 60 pg/mL EO. Apoptosis was induced by activation of caspase-9 (Jo et al., 2012). Soeur et al. (2011) found ihdXAniba rosaeodora Ducke (Lauraceae) had cytotoxic effects against A431 (human epidermoid carcinoma cell line) and on HaCaT (human keratinocytes) cells. At a concentration... 

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