Cell adhesion glycosphingolipids

Glycosphingolipids are constituents of the outer leaflet of plasma membranes and are important in cell adhesion and cell recognition. Some are antigens, eg, ABO blood group substances. Certain gangliosides function as receptors for bacterial toxins (eg, for cholera toxin, which subsequently activates adenylyl cyclase). 

New insights in glycosphingolipid function glycosignaling do- 85. main, a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling. Biochemistry 1999 38 3369-3378. 86. 

Kojima, N., Shiota, M., Sadahira, Y., Handa, K. and Hakomori, S. (1992). Cell adhesion in a dynamic flow system as compared to static system. Glycosphingolipid-glycosphingolipid interaction in the d3mamic system predominates over lectin- or integrin-based mechanisms in adhesion of B16 melanoma cells to non-activated endothelial cells. J. Biol. Chem. 267, 17264-17270. 

Iwabuchi K, Handa K, Hakomori S Separation of glycosphingolipid signaling domain from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling. J. Biol. Chem. 1998 273 33766-33773. 

Okada, Y., Mugnai, G., Bremer, E. G., and Hakomori, S., 1984, Glycosphingolipids in detergent-insoluble substrate attachment matrix (DISAM) prepared from substrate attachment material (SAM) Their possible role in regulating cell adhesion, Exp. Cell Res. 155 448-456. 

Hakomori S, Igarashi Y. Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling. Adv Lipid Res. 1993 25 147-162. 

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