Glycosphingolipids functions

Glycosphingolipids Function as Structural Components and as Specific Cell Receptors Defects in Sphingolipid Catabolism Are Associated with Metabolic Diseases... 

Thus, the analytical HPLC method for glycolipids is proving useful for a variety of studies related to glycosphingolipid function and metabolism. 

Sillence D. New insights into glycosphingolipid functions—storage, lipid rafts, and translocators. Int. Rev. Cytol. 2007 262 151-189. 

New insights in glycosphingolipid function glycosignaling do- 85. main, a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling. Biochemistry 1999 38 3369-3378. 86. 

Figure 4. Glycosphingolipid function. Glycosphingolipids can interact in a trans fashion with soluble or membrane-bound lectins outside the cell (A). Alternatively, they can interact in a cis fashion with membrane proteins within the same membrane (B).

Glycosphingolipids are constituents of the outer leaflet of plasma membranes and are important in cell adhesion and cell recognition. Some are antigens, eg, ABO blood group substances. Certain gangliosides function as receptors for bacterial toxins (eg, for cholera toxin, which subsequently activates adenylyl cyclase). 

Frank, M. MAL, a proteolipid in glycosphingolipid enriched domains functional implications in myelin and beyond. Prog. Neurobiol. 60, 531-544, 2000. 

The glycosphingolipids differ from sphingomyelin in that they do nflt contain phosphate, and the polar head function is provided by a monosaccharide or oligosaccharide attached directly to the ceramide by... 

The great variety of structures found in the glycosphingolipids of marine invertebrates can provide scientists with rich material for investigations aimed at ascertaining the relationship between the properties and functions of this class of compounds and their structure. 

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