Cartilage applications

Biodegradable polyurethanes are of great interest for medical applications because of their variable mechanical properties, biocompatibility, and structural versatility. They are currently used in bone and cartilage applications, as well as in nerve regeneration. 

The molecular causes of a number of heritable diseases of bone (eg, osteogenesis imperfecta) and of cartilage (eg, the chondrodystrophies) are being revealed by the application of recombinant DNA technology. 

The authors have now reviewed in detail four cases of unexpected death following the use of neck holds in PCP-intoxicated individuals. In all of the cases, multiple carotid compression holds had been attempted, according to the history. Skin abrasions, hemorrhage into the soft tissues of the neck, and fractures of the hyoid bone and thyroid cartilage provide structural evidence of the application of substantial force to the neck. On autopsy, there has been no evidence of lethal injuries to the bronchial tree, bra in, or heart. 

McGann, L.E., Kinetics of osmotic water movement in chontrocites isolated from articular cartilage and application to cryopreservation, /. Orthopedic Res., 6,109,1988. 

In this chapter the application of multichannel IR detector arrays to mammalian tissue is discussed from a practical perspective. The major emphasis will be on the application of the technology to cervical cancer diagnosis focusing on sample preparation, instrumental parameters, data processing techniques and correlation with histology. The next part of the chapter focuses on the application of the technique to arthritis research by investigating the effect of specific antibodies that induce an arthritic type of response in bovine cartilage explants. In the final part of the chapter... 

A number of other processes are in continuous development. Clinical applications of these therapies in the urogenital and cardiovascular systems, in peripheral and central nervous systems, pancreas, joint cartilage restoration, etc., are being studied. However, almost all procedures suffer from a common limitation the availability of donor cells. Cell therapies have to begin with a relatively high number of cells, and stem cells, irrespective of their origin, are always a minor subpopulation in tissues. 

Electrical Properties of Bone and Cartilage Experimental Effects and Clinical Applications" Grune and Stratton ... 

ECMs contain a variety of cell types (see Table 1.2) such as fibroblasts in the skin, chondrocytes in cartilage, and osteoblasts in bone. The role of these cells is to synthesize and deposit the ECM surrounding the cell and to change the amount and location of the ECM in response to trauma and changes in external loading. For instance, collagen synthesis in these cells is typically up-regulated by the application tensile forces and is down-... 

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