Cardiovascular disorders physiology

Other Pathologies. Because of their many varied physiologic effects, the eicosanoids are involved in a number of other pathologic conditions. Prostaglandins have been implicated in cardiovascular disorders (hypertension), neoplasms (colon cancer), respiratory dysfunction (asthma), neurologic disorders (multiple... 

Ion channels are membrane proteins that play essential roles in cell physiology and pharmacology (also see Chapter 13). Consequently they have been identified as potential targets for novel therapeutic compounds in a range of disease areas [76], such as cardiovascular disorders, central and peripheral nervous system disorders, and metabolic disorders. Unfortunately, they are also inextricably linked with the absorption, distribution, metabolism, and excretion/ toxicology (ADME/Tox) profile of other therapeutic compounds—often through unforeseen drug-ion channel interactions [77]. 

Medical conditions based in nearly all physiological systems can produce coincident sleep disturbances and sleep deprivation. This includes disorders of the cardiovascular (chronic heart failure), pulmonary (asthma), gastrointestinal (hepatic failure), renal (urinary tract infections, polyuria), endocrine (diabetes, hypothyroidism, hyperthyroidism), and neurological (Parkinson s disease,... 

Various anatomical, physiological and behavioural risk factors for atherosclerosis are known. Many of these are recognised within the metabolic syndrome , a combination of disorders that increases the risk of developing cardiovascular disease and diabetes. Prevalence increases with age, affecting up to 25% of the population in the USA. Risk factors include ... 

---