Prostatic duct carcinoma

Prostate-specific antigen (PSA) Carcinoma of prostate Salivary duct carcinoma Prostate secretory and ductal epithelium... 

Other enzymes are also useful indices of liver pathology. Serum alkaline phosphatase is often a useful indicator of liver and bone disease. The alkaline phosphatases are a diverse group of enzymes that catalyze reactions in which a phosphate is removed from a phosphate ester, especially at an alkaline pH. Physicians don t care about this. They do care that serum alkaline phosphatase levels often rise with bone breakdown (as in tumor infiltration) and in liver disease, especially where tliere is obstruction of the bile duct. Acid phosphatase is particularly rich in the prostate. A rise in its serum levels provides a test as to the presence of prostate carcinoma. This test has largely been replaced by assay for Prostate Specific Antigen (PSA), a serine protease that is elevated in prostatic carcinoma. 

In a rabbit study, hydroquinone at 150 mg kg day produced minimal developmental alterations in the presence of maternal toxicity. The no-observed-effect level for developmental toxicity was 75mgkg day In rat studies, maternal toxic effects from exposure to hydroquinone included changes in the ovaries, fallopian tubes, and menstrual cycle. Postimplantation mortality was also observed in rat studies. Observed paternal toxic effects from exposure to hydroquinone included changes in the testes, epididymis, sperm duct, prostate, seminal vesicle, Cowper s gland, accessory glands, and male fertility index. Further, exposure to hydroquinone produced skeletal malformations in chickens and ocular and skeletal malformations in rabbits. Hydroquinone can induce renal tubule adenomas, bladder carcinomas, hepatocellular neoplasms, and mononuclear cell leukemia in experimental animals. 

CK1/5/10/14 34betaE12 Basal cells of prostate most duct-derived carcinomas... 

Typically Positive Carcinomas Skin and adnexa, breast, bile ducts, lung, pancreas, salivary gland, urotbelium, endometrium, endocervix, prostate, thyroid... 

Fan CY, Wang J, Barnes EL. Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma an immunohistochemical analysis of 13 cases and review of the literature. Am J Surg Pathol. 2000 24 579-586. 

James GK, Pudek M, Berean KW, et al. Salivary duct carcinoma secreting prostate-specific antigen. Am J Clin Pathol. 1996 106 242. 

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