Carcinogens lipid peroxidation activation

The antagonism or prevention of toxic effects may also benefit from stereochemical principles. Thus, optically active flavanones have been shown to inhibit the metabolic activation of the carcinogen benzo[a]pyrene to metabolites that bind covalently to DNA (Chae et al., 1992). Moreover, the (+) enantiomers of 3-0-methyicatechin and catechin have been demonstrated to protect stereoselectively against lipid peroxidation due to paracetamol (Devalia et al., 1982),... 

Peroxides can play a physiological role in the cell but also mediate processes leading to heart disease and carcinogenesis. Fatty acid peroxidation may also be related to free radical-mediated metabolic activation of carcinogens or drugs, which lead to the initiation of carcinogenesis or cytotoxicity. Modification of membrane function as a consequence of lipid peroxidation includes imcoupling of oxidative phosphorylation... 

Despite most of the compounds did not shown antioxidant activity against free radicals, they were able to inhibit the lipid peroxidation induced by different carcinogens and toxics, also related to thier, also hepatoprotective effect [87, 108-113, 128]. 

Administered at 1.25% and 2.5% of the diet of female rats subjected to carcinogen-induced mammary carcinogenesis, asafetida increased activity levels of endogenous antioxidants (glu-tathione-5-transferase, reduced glutathione, superoxide dismutase, and catalase), inhibited lipid peroxidation, delayed tumor appearance, and reduced the size of tumors. The essential oil showed a relaxant effect on isolated rat ileum. Asafetida has also shown hypotensive activities in animals. It has also been demonstrated to increase blood coagulation time. ... 

Powdered caraway inhibited lipid peroxidation in stored chicken meat. An ethanol extract of the seeds showed greater potency. As a supplement in the diet of mice, the oil inhibited carcinogen-induced skin tumors however, best results were found from topical application of the oil. Carvone and limonene have shown in vitro chemopreventive activity by... 

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