Carcinogenesis thyroid

Hard, G. C. (1998). Recent developments in the investigation of thyroid regulation and thyroid carcinogenesis. Environ. Health Terspcct. 106(8), 427-4.36. 

THOMAS G A, WILLIAMS E D (1999) Thyroid stimulating hormone (TSH)-associated follicular hypertrophy and hyperplasia as a mechanism of thyroid carcinogenesis in mice and rats. lARC Sci Publ. 147 45-59. 

Radiation is carcinogenic. The frequency of death from cancer of the thyroid, breast, lung, esophagus, stomach, and bladder was higher in Japanese survivors of the atomic bomb than in nonexposed individuals, and carcinogenesis seems to be the primary latent effect of ionizing radiation. The minimal latent period of most cancers was <15 years and depended on an individual s age at exposure and site of cancer. The relation of radiation-induced cancers to low doses and the shape of the dose-response curve (linear or nonlinear), the existence of a threshold, and the influence of dose rate and exposure period have to be determined (Hobbs and McClellan 1986). 

Carcinogenesis There has been evidence of oncogenic activity in studies with oxytetracycline (adrenal and pituitary tumors) in rats and minocycline (thyroid tumors) in rats and dogs. 

Anti-thyroid activity. Boiled rice taken orally by adults at a dose of 350 g/person was inactive on iodine uptake by the thyroid Anti-tumor activity. Bran, administered intraperitoneally to mice at a dose of 100 mg/kg, was active on Sarcoma 180 (solid). The biological activity has been patented . Fermented grains, in the ration of rats, were active. Miso, a paste made from the seeds of Oryza sativa and G lycine max (soybean), was fed ad libitum. The incidence of cancers in the miso treated rats was 20% less than controls vs 7,12-dimethylbenz-[a]anthracene -induced carcinogenesis ". Water extract of dried seed hull, administered intraperitoneally to mice, was active on Sarcoma 180 (ASC). A glycoprotein fraction has been tested. The biological activity reported has been patented . Anti-ulcer activity. A cerebroside fraction of rice bran, administered intraperitoneally to mice at a dose of 100 mg/kg, was inac-... 

Ron, E. and Modan, B. (1984). Thyroid and other neoplasms following childhood scalp irritation, page 139 in Radiation Carcinogenesis Epidemiology and Biological Significance, BOICE, J.D., jR. AND Fraumeni, J.F., jR., Eds. (Raven Press, New York). 

Shirai, T., Masuda, A., Imaida, K., Ogiso, T. Ito, N. (1988) Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with A -bis(2-hydroxypropyl)nitrosamine. Jpn. J. Cancer Res., 79,460 65... 

Several features of the carcinogenicity results on ethylene thiourea deserve discussion. Not all of the animals in a given dose group developed thyroid tumors over the course of their exposures only a fraction of each group did. Another name for this fraction is lifetime tumor incidence still another is lifetime risk (probability) of tumor development. Second, the lifetime risk of tumor development, or, since in the definition of carcinogenesis tumors were equated with can-... 

I ARC (1999a). Species differences in thyroid, kidney and urinary bladder carcinogenesis. lARC Sci Pub 147, 1-225. 

The distribution of p53 has been examined in cases of thyroid carcinoma. In the series reported by Soares and coworkers, p53 was absent from 14 cases of goiter and adenoma and from 12 cases of papillary carcinoma. p53 was present in 20% of follicular carcinomas (predominantly of the widely invasive type), 16% of poorly differentiated carcinomas, and 67% of undifferentiated carcinomas. In the series reported by Holm and Nesland, 6 of 32 (19%) papillary carcinomas, 5 of 29 (17%) follicular carcinomas, and 18 of 24 (75%) undifferentiated carcinomas were p53-F. In contrast, the RB gene product was present in all thyroid carcinomas, suggesting that it does not play a major role in thyroid carcinogenesis. "... 

Hill RN, Erdreich LS, Paynter OE, Roberts PA, Rosenthal SL, Wilkinson CP (1989) Thyroid follicular carcinogenesis, fund Appl Toxicol 12 629-697... 

Takagi, H., K. Mitsumori, H. Onodera, M. Nasu, T. Tamura, K. Yasuhara, K. Takegawa, and M. Hrrose. 2002. Improvement of a two-stage carcinogenesis model to detect modifying effects of endocrine disrupting chemicals on thyroid carcinogenesis in rats. Cancer letters 178 1-9. 

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