Carcinogenesis studies, tumor

Thorgeirsson UP, Dalgard DW, Reeves J, et al Tumor incidence in a chemical carcinogenesis study of nonhuman primates. Reg Toxicol Pharmacol 19 130-151, 1994... 

Complete Carcinogenesis Studies. Studies in laboratory animals have demonstrated the ability of benz[a]anthracene, benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[a]pyrene, chrysene, dibenz[a,h,]anthracene, and indeno[1,2,3-c,d]pyrene to induce skin tumors (i.e., they are complete carcinogens) following intermediate dermal exposure. Anthracene, fluoranthene, fluorene, phenanthrene, and pyrene do not act as complete carcinogens. The data supporting these conclusions are discussed below by chemical. Only those studies considered adequate and reliable with respect to study design and adequacy of reporting are presented in Table 2-3. 

Hecht, S.S., R.L. Thome, and D. Hoffmann Smdies on tumor promoters in tobacco smoke 28th Tobacco Chemists Research Conference, Program Booklet and Abstracts, Vol. 28, Paper No. 42, 1974, p. 28, for presentation text, see www.ijrtdocs.com 501527005 -7015. Hecht, S.S., R.L. Thome, R. Maronpot, and D. Hoffmann A study of tobacco carcinogenesis. XIII. Tumor promoting subfractions of the weakly acidic fraction J. Natl. Cancer Inst. 55 (1975) 1329-1336. 

Hoffmann, D. and E.L. Wynder Chemical analysis and carcinogenic bioassays of organic particulate pollutants in Air pollution, Vol. 2, 2nd Edition, edited by A.C. Stem, Academic Press, New York, NY (1968) 187-247. Hoffmann, D. and E.L. Wynder A study of tobacco carcinogenesis. XL Tumor initiators, tumor accelerators, and tumor promoting activity of condensate fractions Cancer 27 (1971) 848-864. 

Wynder, E.L. and D. Hoffmann A study of tobacco carcinogenesis. X. Tumor promoting activity Cancer 24... 

Studies with experimental animals have shown that dietary sphingolipids significantly reduce the early stages of colon carcinogenesis and tumor formation, but knowledge about the amount and... 

A scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). It contains some 8,000 chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primaiy journals, current awareness tools, NCI reports, and other special sources. Test results have been reviewed by experts in carcinogenesis and mutagenesis. 

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