Dietary sphingolipids

Imaizumi, K., Tominaga, A., Sato, M., and Sugano, M. 1992. Effects of dietary sphingolipids on levels of serum and liver lipids in rats. Nutr. Res. 12, 543-548. 

Berra, B., Colombo, I., Sottocornola, E., Giacosa, A. 2002. Dietary sphingolipids in colorectal cancer prevention. Eur. J. Cancer Prev. 11, 193-197. 

Evidence suggests that dietary sphingolipids, acting through their hydrolysis products, ceramide and sphingosine, can inhibit the development of colon cancer (Duan, 1998 Vesper et al., 1999). In milk fat, sphingomyelin is by far the predominant sphingolipid. 

Schmelz, E.M., Dillehay, D.L., Webb, S.K., Reiter, A., Adams, J., Merrill, A.H. 1996. Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine implications for dietary sphingolipids and colon carcinogenesis. Cancer Res. 56,4936 1941. 

FIGURE 5.1 Tumor suppression by dietary sphingolipids. (From Schmelz, E.M., Br. Nutr. Found. Nutr. Bull., 25, 135, 2000. With permission.)... 

Studies with experimental animals have shown that dietary sphingolipids significantly reduce the early stages of colon carcinogenesis and tumor formation, but knowledge about the amount and... 

Schmelz, E.M. Dietary sphingomyelin and other sphingolipids in health disease. Nutr. Bull 2000,... 

Symolon, H., Schmelz, E.M., DiUehay, D.L., and Merrill, A.H. Jr., Dietary soy sphingolipids snppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CFl mice and ApcMin/+ mice,... 

Hazelnut, which contains lipid-lowering bioactives such as MUFA, PUFA, phytosterols, phytostanols, polyphenols, and sphingolipids [11,12,107,117,140,141,147,175,183,189,203-205], offers an opportunity as a potential hypercholesterolemic heart-healthy diet component In addition to these bioactives and minor components, there are a number of nonfat constituents (such as essential minerals, essential amino acids, antioxidant phenoUcs, soluble dietary fiber, and phytochemicals, among others) in hazelnut that may elicit additional cholesterol-lowering and cardioprotective effects [11,57,59,85,117,174,206]. 

---