Carcinogenesis research

Carcinogenesis research has demonstrated the tumorigenic activities of a large number of chemical substances in experimental animals. These include molecules of diverse chemical classes, organic and inorganic, and natural products as well as compounds synthesized in the laboratory or produced by industry. 

This book is expected to be of interest to investigators active in all aspects of carcinogenesis research as well as to graduate students, educators, and others seeking an introduction to this important field of research. 

Recent advances in PAH carcinogenesis research over the past decade have led to identification of diol epoxide metabolites as the principal active forms of the PAH investigated to date Q,2). Benzo-(a)pyrene (BP) has been most intensively investigated, and it has been demonstrated that a diol epoxide metabolite anti-BPDE is the active intermediate which binds covalently to DNA in human and other mammalian tissues 0,4). Anti-BPDE was also demonstrated to be a powerful mutagen in both bacterial and mammalian cells (15) These findings stimulated an outpouring of research directed towards elucidation of the molecular mechanism of PAH carcinogenesis. 

CCRIS. 1998. Chemical Carcinogenesis Research Information System. National Library of Medicine, National Toxicology Information Program, Bethesda, MD. May 11, 1998. 

CCRIS Chemical Carcinogenesis Research Information System... 

Saffiotti, U. (1975). Symposium Current progress in pancreatic carcinogenesis research, Cancer Res. 35,2223. 

Chemical Carcinogenesis Research Information System, TOXNET, http //toxnet.nlm.nih.gov. 

Flarris CC. 1987. Fluman tissues and cells in carcinogenesis research. Cancer Res 47 1-10. Hartzell G. 1977. Physiological and behavioral responses to fire combustion products. Presented at 4th Annual Meeting Fire Retard Chem Assoc. Toxic Prod Combust, 175-202. 

Hendricks, J.D., T.R. Meyers, J.L. Casteel, J.E. Nixon, P.M. Loveland and G.S. Bailey. Rainbow trout embryos advantages and limitations for carcinogenesis research. Natl. Cancer Inst. Monogr. 65 129-137, 1984. 

CCRIS (Chemical Carcinogenesis Research Information System) http //toxnet.nlm. nih. gov/cgi-bin/sis/ htmlgen CCRIS Sponsored by the National Cancer Institute (NCI http //www.nci. nih.gov/), CCRIS contains scientifically evaluated data derived from carcinogenicity, mutagenicity, tumor promotion and tumor inhibition tests on about 8,000 chemicals. 

Explorations of cellular and animal models in carcinogenesis research... 

Chemical Carcinogenesis Research Information System). Produced by the National Cancer Institute, National Institutes of Health, USA. CCRIS contains data on carcinogenicity and mutagenicity test results. At December 1991 it includes test results for 3134 chemicals. 

CCRIS Chemical Carcinogenesis Research Information System (CCRIS). System includes carcinogenicity and mutagenicity test results for over 8000 chemicals http //toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen7CCRlS... 

CCRIS—Chemical Carcinogenesis Research Information System contains carcinogenicity and mutagenicity information for over 8000 chemicals. 

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