Etoposide Carboplatin

Jeremic B, Shibamoto Y, Acimovic L, et al. Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage M non-small cell lung cancer a randomized study. J Clin Oncol 1996 14 1065-1107. 

Carboplatin/Etoposide Ethacrynic acid Inhalation anesthetics Phenytoin Tricyclic antidepressants... 

ICE Ifosfamide, carboplatin, etoposide Nonsmall cell lung cancer... 

Amsacrine Aclarubicin Carboplatin Etoposide phosphate Asparaginase... 

A number of cytotoxic agents have demonstrated significant singleagent activity in chemotherapy-naive patients with limited- and extensive-disease SCLC, but the activity in recurrent or refractory SCLC is modest. Among the more commonly used chemotherapy agents in the United States are cisplatin, carboplatin, etoposide (intravenous and oral regimens), topotecan, paclitaxel, docetaxel, and gemcitabine. 

Reck M, von Pawel J, Macha HN, et al. Randomized phase III trial of paclitaxel, etoposide, and carboplatin versus carboplatin, etoposide, and vincristine in patients with small-cell lung cancer. J Natl Cancer Inst 2003 95 1118-1127. 

JP is receiving a highly myelosuppressive chemotherapy regimen for the next 3 days for his lymphoma. The chemotherapy orders specify ifosfamide, carboplatin, and etoposide. The goal of this cycle of chemotherapy is to put the cancer into remission so that his lymphoma can be cured with a bone marrow transplant. 

CAV, cyclophosphamide, doxorubicin, vincristine EC, etoposide carboplatin EP, etoposide cisplatin IC, irinotecan, cisplatin. See Table 87M for doses and schedules. 

The most frequently used regimen is cisplatin or carboplatin combined with etoposide. Irinotecan in combination with cisplatin has also been shown to be active (see Table 63-1). Overall response rates and survival durations are generally superior for patients with limited stage versus those with extensive stage disease. 

ICE (ifosfamide, carboplatin, and etoposide) appears to be better tolerated than cisplatin-containing regimens, especially in elderly adults. 

Chemotherapeutic agents that have significant cancer response when combined with hyperthermia (up to 43°C) include doxorubicin, melphalan, mitomycin C (MMC), mitoxantrone, gemcitabine, etoposide, and especially the platinum-based agents carboplatin and oxaliplatin (Mohamed et al., 2003 Sugarbaker et al., 2005). Agents that do not work well with hyperthermia include irinotecan, paclitaxel, docetaxel, 5-fluorouracil, and floxuridine (Mohamed et al., 2003 Sugarbaker et al., 2005). 

Hainsworth JD, Gray JR, Stroup SL, Kalman LA, Patten JE, Hopkins LG, Thomas M, Greco FA. Paclitaxel, carboplatin, and extended-schedule etoposide in the treatment of small-cell lung cancer comparison of sequential phase II trials using different dose-intensities. J Clin Oncol 1997 15(12) 3464—3470. 

The RT consisted of 45 Gy in 3 wk using 1.5 Gy bid concurrent with either cisplatin/etoposide or carboplatin/vindesine after the same drugs had been given alone at higher dosage. Acute toxicity was acceptable and treatment-related deaths were 9% or... 

IEP = ifosfamide, etoposide, cisplatin PEP = cisplatin, etoposide, paclitaxel EP = etoposide + cisplatin TP = topotecan+ paclitaxel E Carbo = etoposide + carboplatin. 

Metastatic osteosarcoma has a poor prognosis unless the disease is confined to the lungs and is resectable. Palliative chemotherapy can be employed with a number of drugs including doxorubicin, cisplatin, carboplatin, methotrexate, ifosfamide and etoposide. 

Reconstitution of full-length BRCAl into mouse embryonic fibroblast cells with a disrupted BRCAl led to an increase in resistance to several DNA damaging agents, including the platinum compounds carboplatin and oxaliplatin, the topoisomerase 1 drugs irinotecan and topotecan, and the topoisomerase 11 drugs doxorubicin and etoposide (61). 

Williams, P.C., et al. 1995. Toxicity and efficacy of carboplatin and etoposide in conjunction with disruption of the blood-brain tumor barrier in the treatment of intracranial neoplasms. Neurosurgery 37 17. 

Pediatric glioma 7 Daunorubicin + free carboplatin and etoposide IV Daunorubicin day 1 and 2 carboplatin and etoposide day 1 5/7 Showed positive response with monthly treatment... 

Moreover, Fiorillo et al. [393] studied the effect of a combination of liposomal daunorubicin, etoposide, and carboplatin administered to seven children with recurrent malignant supratentorial brain tumors as a second-line therapy. Chemotherapy consisted of infusion of liposomal daunorubicin on days 1 and 2 and infusion of etoposide and carboplatin on day 1 whereas courses were repeated every 3M weeks. After a total of eight courses, five of seven children evaluated were alive 12-64 months after diagnosis and 8-29 months from the start of the second-line chemotherapy. Of the seven children, three showed complete response, two partial responses, one stable disease, and one progressive disease. The time to the best response was 3-10 months, while the median time to progression was 23 months. The toxicity observed was minimum. 

Fiorillo, A., Maggi, G., Greco, N., Migliorati, R., D Amico, A., Del Basso De Caro, M., Sabbatino, M. S., and Buffardi,F. (2004), Second-line chemotherapy with the association of liposomal daunorubicin, carboplatin and etoposide in children with recurrent malignant brain tumors,/. Neuro-Oncol., 66,179-185. 

The most frequently used regimen is cisplatin or carboplatin combined with etoposide. Irinotecan in combination with cisplatin has also been... 

Discrete cutaneous hyperpigmentation occurred in two patients after high-dose chemotherapy with cyclophosphamide, etoposide, and carboplatin (29). 

Prussick R, Horn TD, Wilson WH, Turner MC. A characteristic eruption associated with ifosfamide, carboplatin, and etoposide chemotherapy after pretreatment with recombinant interleukin-1 alpha. J Am Acad Dermatol 1996 35 (5 Pt l) 705-9. 

A 52-year-old patient with glioblastoma developed severe ocular and orbital toxicity after receiving intracarotid etoposide phosphate and carboplatin (268). Acutely non-pupiUary block angle-closure glaucoma developed secondary to uveal effusion in the ipsilateral eye. Four days later, severe orbital inflammation resulted in reduced visual acuity, proptosis, optic neuropathy, and total external ophthalmoplegia. 

Lauer AK, Wobig JL, Shults WT, Neuwelt EA, Wilson MW. Severe ocular and orbital toxicity after intracarotid etoposide phosphate and carboplatin therapy. Am J Ophthalmol 1999 127(2) 230-3. 

Clinically important, potentially hazardous interactions with altretamine, amikacin, aminoglycosides, antineoplastics, bleomycin, busulfan, carboplatin, carmustine, chlorambucil, cisplatin, corticosteroids, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin, docetaxel, doxorubicin, estramustine, etoposide, fludarabine, fluorouracil, gemcitabine, gentamicin, hydroxyurea, idarubicin, ifosfamide, indomethacin, kanamycin, levamisole, lomustine, mechlorethamine, melphalan, mercaptopurine, methotrexate, mitomycin, mitotane, mitoxantrone, neomycin, pentostatin, plicamycin, procarbazine, streptomycin, streptozocin, thioguanine, thiotepa, tobramycin, tretinoin, uracil, vinblastine, vincristine, vinorelbine... 

Leyvraz S, Pampallona S, Martinelli G et al (2008) A threefold dose intensity treatment with ifosfamide, carboplatin, and etoposide for patients with small cell lung cancer a randomized trial. J Natl Cancer Inst 100 533-541... 

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