Carbon monoxide poisoning antidote

Combined intoxications of carbon monoxide and cyanide should not be treated with the nitrites found in cyanide antidote kits. These nitrites are used to create methemoglobinemia, which will exacerbate carbon monoxide poisoning by further reducing the ability of the blood to deliver oxygen to body tissue. 

In addition, other chemicals such as a-adrenergic blocking agents like chlorpromazine (O Flaherty and Thomas 1982 Way and Burrows 1976) or oxygen (Burrows et al. 1973 Sheehy and Way 1968) may be used to enhance the protective action of other antidotes. However, the mechanism of their action is not well understood. Further research for a potent and safe antidote, particularly among smoke inhalation victims who have carbon monoxide poisoning, to mitigate cyanide toxicity is desirable. 

Carbon monoxide poisoning is treated with O2 that displaces the CO from hemoglobin receptors. Antidotes function by antagonizing the toxicity of a poison. 

In addition to antidotal therapy, administration of 100% oxygen can help with cyanide detoxification, possibly by affecting the binding of cyanide to cytochrome oxidase (13). Hyperbaric therapy may be considered, but only after standard treatment has failed, or if the patient has concurrent carbon monoxide poisoning (13). 

Antidotes that antagonised other macromolecules e.g. carbon monoxide produce poisonous condition by binding the haemoglobin and other cellular components. 

In certain poisoning cases a specific antidote may be available, e.g. for carbon monoxide,... 

After 1945, it was not unusual for chemists to cast a veil of silence over their involvement in the crimes of the Nazi regime. Deichmann ([19], p. 414) brought up this painful subject In contrast to prominent German physicists, who professed after the war that they had not been in favour of the production of the atomic bomb for moral reasons, neither Staudinger nor other chemists claimed that they were unable to synthesise an artificial fibre, an explosive, a poison gas or an antidote because they had not wanted to for moral reasons. They were honest about this. However, Staudinger (and all his fellow chemists) failed to comment on the enormous crimes that were committed with the involvement of chemists. [...] The killing of mentally disturbed Germans by carbon monoxide and of European Jews by Zyklon B (is, editor s note) not mentiOTied. ... 

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