Cyanide antidote kits

For cyanide and cyanogen, antidote should be administered as soon as possible. The Lilly Cyanide Antidote Kit contains amyl nitrite, sodium nitrite, and sodium thiosulfate. Cobalt edentate or 4-dimethylaminophenol are alternative antidotes for cyanide poisoning. Benzodiazepines or barbiturates may be required to control severe seizures. 

Combined intoxications of carbon monoxide and cyanide should not be treated with the nitrites found in cyanide antidote kits. These nitrites are used to create methemoglobinemia, which will exacerbate carbon monoxide poisoning by further reducing the ability of the blood to deliver oxygen to body tissue. 

Antidotes Intravenous sodium nitrite and sodium thiosulfate, and/or amyl nitrite perles are packaged in the cyanide antidote kit. When possible, treatment with cyanide antidotes... 

Cyanogen Inhalation, skin absorption, ingestion, Irritating to eyes and upper respiratory The Lilly Cyanide Antidote Kit contains amyl nitrite, sodium... 

Amyl nitrite, Na Nitrite, Na Thiosulfate Cyanide antidote kit) Cyanide... 

Cyanide Antidote Kit (See Amyl Nitrate. Sodium Nitrite, and Sodium Thiosulfate) Rumazenil (Romazicon)... 

O2, IV fluid, pressors, cyanide antidote kit, Cyanokit, sodium bicarbonate, anticonvulsants for Szs O2, charcoal, atropine (bradycardia), antiar-rhythmic (lidocaine, amiodarone)... 

Treatment No specific antidote some authorities recommend the nitrite portion of the conventional cyanide antidote kit. 

The North Atlantic Treaty Organization (NATO) and the U.S. military consider cyanide a possible weapon of so-called rogue nations such as Iraq, Iran, and North Korea, and terrorist groups. Iraq is believed to have used cyanide to kill thousands in the 1980s during its war with Iran and against Kurds in northern Iraq. With this in mind, the possibility of an antidote takes on added importance. However, the effectiveness of amyl nitrite as an antidote for cyanide poisoning has come under question by some medical authorities. The U.S. military removed amyl nitrite from its cyanide antidote kits, because of adverse side effects (low blood pressure, dizziness, and headaches) and other concerns. 

If one were forced to choose between equipping ambulances with extra atropine autoinjectors in the event of a nerve agent release or instead equip these with cyanide antidote kits, which would you choose Why ... 

The cyanide antidote kit contains amyl nitrate, sodium nitrate, and sodium thiosulfate. Nitrates convert hemoglobin to methemoglobin, which in turn competes for cyanide with the mitochondrial oxidase complex. Amyl nitrate pearls, administered by inhalation, can be utilized as a first aid measure when intravenous (IV) access is impossible or will be delayed. If IV access is available, IV sodium nitrate is preferred, followed by sodium thiosulfate. Sodium thiosulfate reacts with cyanide to form nontoxic thiocyanate, which is then excreted into the urine. 

Similarly, therapeutics that detoxify the chemical agent from systemic circulation, such as protein scavengers of nerve agent or newer cobalamine-based molecules that bind and scavenge cyanide, could work as well. The Cyanide Antidote Kit has been used for several years to remove... 

Amyl nitrite is a vasodilator that acts by relaxing vascular smooth muscle. It is also a component of the Taylor Cyanide Antidote Kit. 

In asymptomatic patients, activated charcoal and observation may be all that is necessary. In the unlikely event that patients exposed to hydrangea develop symptoms consistent with cyanide poisoning, ignore gastric decontamination procedures until life-support measures have been instituted. Cyanide antidote kit administration may be necessary. 

Treatment involves the use of activated charcoal in order to prevent amygdalin metabolism. In addition, there is a cyanide antidote kit available. 

Amyl nitrite, sodium nitrite, and sodium thiosulfate are commercially available in standard doses in the Pasadena Cyanide Antidote Kit. This kit is not widely distributed in Department of Defense medical channels. No antidote kits are provided to naval personnel far forward. However, should a person be exposed to a lethal dose of the agent and not receive therapy immediately, death is certain. 

Cyanide antidote kit (Amyl nitrite, sodium nitrate, and Cyanide... 

Kirk MA, Gerace R and Kulig KW (1993). Cyanide and methemoglobin kinetics in smoke inhalation victims treated with the cyanide antidote kit. Ann Emerg Med, 22, 1413-1418. 

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