Carbohydrates Quantum dots

R. Kikkeri, B. Lepenies, A. Adibekian, P. Laurino, and P. H. Seeberger, In vitro and in vivo liver targeting with carbohydrate capped quantum dots, J. Am. Chem. Soc., 131 (2009) 2110-2112. 

B. Mukhopadhyay, M. B. Martins, R. Karamanska, D. A. Russell, and R. A. Field, Bacterial detection using carbohydrate-functionalised CdS quantum dots A model study exploiting E. coli recognition of mannosides, Tetrahedron Lett., 50 (2009) 886-889. 

C. Earhart, N. R. Jana, N. Erathodiyil, and J. Y. Ying, Synthesis of carbohydrate-conjugated nanopartieles and quantum dots, Langmuir, 24 (2008) 6215-6219. 

J. D. M. de la Fuente and S. Penades, Glyco-quantum dots A new lumineseent system wifli multivalent carbohydrate display. Tetrahedron Asymmetry, 16 (2005) 387-391. 

S. A. Svarovsky and J. J. Barchi, De novo syndiesis of biofunctional carbohydrate-encapsulated quantum dots, in A. V. Demchenko, (Ed.), Frontiers in... 

A. Robinson, J.-M. Fang, P.-T. Chou, K.-W. Liao, R.-M. Chu, and S.-J. Lee, Probing lectin and sperm with carbohydrate-modified quantum dots, ChemBio-Chem, 6 (2005) 1899-1905. 

De Novo Synthesis of Biofunctional Carbohydrate-Encapsulated Quantum Dots... 

In summary, a simple, one-pot aqueous synthesis of robust, luminescent Tr MAA(mTEG) hybrid CdTe quantum dots is reported for the first time. The novelty of this method is several-fold. First is the use of two distinct capping agents, one that promotes the growth and luminescence and the other that provides biofiinctionality. Second, the synthesis can be carried out under relatively low temperature and under different pH conditions with no detrimental effect on the carbohydrate unit. Third, the color (size) of the QDs is controlled solely by duration of the synthesis. Fourth, these QDs maintain their stability in the absence of free ligand in solution. With the incorporation of mTEG into... 

Svarovsky SA, Barchi JJ Jr (2007) De novo sunthesis of biofunctional carbohydrate-encapsulated quantum dots. ACS Symp Ser 960 375-392... 

Yang Y, Yu M, Yan T-T et al (2010) Characterization of multivalent lactose quantum dots and its application in carbohydrate-protein interactions study and cell imaging. Bioorg Med Chem 18 5234-5240... 

Scheme 11.2-3 2-(2-(2-Mercaptoethoxy) removed from carbohydrate and thiol, ethoxyjethanol as a linker for preparing c - Reduced thiol coupled to maleimide or neoglycoconjugates a - Linker synthetically iodoacetyl functionalized structure (chip, incorporated into reducing end of mono- or bead, resin, fluorescent dye, quantum oligosaccharide, b - All protecting groups dot, etc.).

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