Carbohydrates, Deoxysugars, and Sugar Phosphate Synthesis

Simple aldehydes, for example, formaldehyde, acetaldehyde, propanal, butanal, rendered aldol adduct (i.e., 70-75) with exquisite stereoselectivity, a fact which is 

Examples of the chemo enzymatic synthesis of iminocyclitols, pipecolic acid, and aminocyclitols mediated by wild-type FSA and variants, (a) Aldol addition of DHA, HA, HB, or GO catalyzed by wild-type FSA and variants and (b) reductive amination with Hj catalyzed by Pd/C. 

Multistep chemo-enzymatic synthesis of polyhydroxylated pipecolic acid (67) derivatives and homoiminocyclitols (68) by two consecutive aldol addition reactions, (a) t-serine hydroxy-methyltransferase from Streptococcus thermophllus (lSH-(b) Cbz-OSu CH CN/aqueous HCI (c) Cbz-OSu MeOH/SO Cl CaCI, NaBH, EtOH/THF CHjCN/aqueous HCI (d) D-threonine aldoiase from Achromobacterxylosoxidans (oThrA 1 (e) FSA A129S/A165G for R =CH OH, FSA wild type for R = CH FSA A129G for R = H and (f) H, Pd/C. 

10 RECENT ADVANCES IN ENZYME-CATALYZED ALDOL ADDITION REACTIONS 

Examples of carbohydrates, deoxysugars and sugar phosphate compound accessible by FSA catalysis. 

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