Enzyme-catalyzed Aldol Additions

Several cyditol derivatives of varying ring size, for example, (69)/(70), have been prepared based on an enzymatic aldolization as the initial step. Substrates carrying suitably installed C,H-acidic functional groups such as nitro, ester, phosphonate (or halogen) functionalities made use of facile intramolecular nucleophilic (or radical) cyclization reactions ensuing, or subsequent to, the enzyme-catalyzed aldol addition (Figure 10.27) [134—137]. 

Fessner, W.-D. (2004) Enzyme-catalyzed aldol additions, in Modern Aldol Reactions, vol. 1 (ed. R. Mahrwald), Wiley-VCH, Weinheim, pp. 201-272. 

Fessner W-D (1995) Enzyme Catalyzed Aldol Additions. In Helmchen G, Hoffmann RW, Mulzer J, Schaumann E (eds) Houben-Weyl, Methods of Organic Chemistry. Stereoselective Synthesis. Thieme, Stuttgart, vol. E 21b, p 1736... 

Eyrisch, O, Sinerius, G, Fessner, W-D, Eacile enzymic de novo synthesis and NMR spectroscopic characterization of D-tagatose 1,6-bisphosphate, Carbohydr. Res., 238, 287-306, 1993. Henderson, I, Sharpless, KB, Wong, C-H, Synthesis of carbohydrates via tandem use of the osmium-catalyzed asymmetric dihydroxylation and enzyme-catalyzed aldol addition reactions, J. Am. Chem. Soc., 116, 558-561, 1994. 

P. Clapes, 1. loglar, Enzyme-Catalyzed Aldol Additions, in R. Mahrwald (Ed.), Modem Methods in Stereoselective Aldol Reactions, lohn Wiley Sons Ltd, 2013, pp. 475-528. 

W.-D. Fessner, Enzyme-catalyzed aldol additions, in M. Rainer (Ed.), Modern Aldol Reactions. Enolates, Organocatalysis, Biocatalysis and Natural Product Synthesis, Wiley-VCH Verlag GmbH Co. KgaA, Weinheim, 2004, pp. 201 -272. 

Recent Advances in Enzyme-Catalyzed Aldol Addition Reactions... 

RECENT ADVANCES IN ENZYME-CATALYZED ALDOL ADDITION REACTIONS... 

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