Carbohydrates carbohydrate-protein interactions

Lindhorst TK (2002) Artificial Multivalent Sugar Ligands to Understand and Manipulate Carbohydrate-Protein Interactions. 218 201-235 Lindhorst TK, see Rockendorf N (2001) 217 201-238... 

G. Thoma, M. B. Streiff, A. G. Katopodis, R. O. Duthaler, N. H. Voelcker, C. Ehrhardt, and C. Masson, Non-covalent polyvalent ligands by self-assembly of small glycodendrimers A novel concept for the inhibition of polyvalent carbohydrate-protein interactions in vitro and in vivo, Chem. Eur. J., 12 (2006) 99-117. 

D. Zanini and R. Roy, Architectonic neoglycoconjugates Effects of shapes and valencies in multiple carbohydrate-protein interactions, in Y. Chapleur, (Ed.),... 

Clarke, A.E., Wilson, I.A. (eds.) (1988) Carbohydrate—Protein Interactions. Springer-Verlag, Fleidelberg, Germany. 

RM Nelson, A Venot, MP Bevilacqua, RJ Linhardt, I Stamenkovic. Carbohydrate-protein interactions in vascular biology. Annu Rev Cell Dev Biol 11 601-631, 1995. 

Carbohydrate-protein interactions have gained particular interest because of implications in areas such as ceU-specihc drug delivery (Dwek 1996). 

Srinivas O, Narayanaswamy J. Synthetic multivalent glycoclusters and their importance to probe intricate carbohydrate-protein interactions. Proc Ind Natl Sci Acad 2005 71 A 187-211. 

Zanini D, Roy R. Architectonic neoglycoconjugates effects of shapes and valences in multiple carbohydrate-protein interactions. In Chapleur Y, editor. Carbohydrate mimics. Weinheim Wiley-VCH 1998a. pp. 385-415. 

The recognition step, the first event in carbohydrate protein interactions, is dependent on the overall conformation of the oUgosac aride in aqueous solution. Therefore, it is important to determine whether the conformational characteristics of the natural compounds are reflected in the substrate analogues. The most usual methods to achieve this goal is the combination of NMR spectroscopy, molecular mechanics calculations and X-ray data. On this basis, only few conformational studies of thiodisaccharides were reported. 

Once multivalent carbohydrate-protein interactions are firmly established with the assistance of neoglycoconjugates such as those described above, further focus toward fine-tuned geometry and valency requirements becomes necessary for a thorough understanding of the binding interactions involved. Until now, these investigations have been more or less dependent on trial and error which... 

Good treatment of the chemical basis of carbohydrate-protein interactions. 

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