Carbohydrate metabolism glycolysis

Carbohydrate Metabolism Glycolysis/ Gluconeogenesis Citrate cycle (TCA cycle)... 

In the erythrocyte, glycolysis, the pentose phosphate pathway, and the metabolism of 2,3-bisphosphoglycerate (Chapter 28) are the predominant pathways of carbohydrate metabolism. Glycolysis supplies ATP for membrane ion pumps and NADH for reoxidation of methemoglobin. The pentose phosphate pathway supplies NADPH to... 

Carbohydrate Metabolism Glycolysis and the Pentose Phosphate Pathway. 

Triose-phcfiphate isomerase (TIM) (EC 5.3.1.1) and phosphoglycerate kinase (PGK) (EC 2.7.2.3) are two ubiquitous enzymes in the major pathways of carbohydrate metabolism (glycolysis, gluconeogenesis, and pentose phosphate pathway), catalyzing the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate, and the phospho-group transfer between... 

In spite of the number of different structural types, lipids shar e a common biosynthetic origin in that they are ultimately derived from glucose. During one stage of carbohydrate metabolism, called glycolysis, glucose is converted to lactic acid. Pyruvic acid is an intermediate. 

Glycolysis is the major route of carbohydrate metabolism in all cell types and the TCA is a focal point allowing the integration of carbohydrate, amino acid and lipid metabolism. The two pathways are illustrated in Figures 3.9 and 3.14. These two well-known pathways exemplify many of the general principles of metabolic regulation described above. 

The calorific capacity of amino acids is comparable to that of carbohydrates so despite their prime importance in maintaining structural integrity of cells as proteins, amino acids may be used as fuels especially during times when carbohydrate metabolism is compromised, for example, starvation or prolonged vigorous exercise. Muscle and liver are particularly important in the metabolism of amino acids as both have transaminase enzymes (see Figures 6.2 and 6.3 and Section 6.4.2) which convert the carbon skeletons of several different amino acids into intermediates of glycolysis (e.g. pyruvate) or the TCA cycle (e.g. oxaloacetate). Not all amino acids are catabolized to the same extent... 

Fructose 2,6-bisphosphate (Fru-2,6-bP) plays an important part in carbohydrate metabolism. This metabolite is formed in small quantities from fructose 6-phosphate and has purely regulatory functions. It stimulates glycolysis by allosteric activation of phosphofructokinase and inhibits gluconeogenesis by inhibition of fructose 1,6-bisphosphatase. 

The ozone treatment apparently initiated changes in the pathways of carbohydrate metabolism, with glycolysis being reduced while the activity of the pentose phosphate pathway was increased. Rat lung tissue exposed to ozone also exhibited the ozone-induced depression of GPD and enhancement of G6PD activity (, 10), The activation of the pentose phosphate pathway is a characteristic featiire of diseased plants (11, 12),... 

Carbohydrate metabolism in a typical plant cell is more complex in several ways than that in a typical animal cell. The plant cell carries out the same processes that generate energy in animal cells (glycolysis, citric acid cycle, and oxidative phosphorylation) it can generate hexoses from three- or four-carbon compounds by glu-coneogenesis it can oxidize hexose phosphates to pentose phosphates with the generation of NADPH (the ox-... 

Glucose 6-phosphate is the key intermediate in carbohydrate metabolism. It may be polymerized into glycogen, dephosphorylated to blood glucose, or converted to fatty acids via acetyl-CoA. It may undergo oxidation by glycolysis, the citric acid cycle, and respiratory chain to yield ATP, or enter the pentose phosphate pathway to yield pentoses and NADPH. 

Potassium [7440-09-7], K, is the third element in the alkali metal series. The name designation for the element is derived from potash, a potassium mineral the symbol from the German name kalium, which comes from the Arabic qili, a plant. The ashes of these plants (a/ qih) were the historical source of potash for preparing fertilizers (qv) or gun powder. Potassium ions, essential to plants and animals, play a key role in carbohydrate metabolism in plants. In animals, potassium ions promote glycolysis, lipolysis, tissue respiration, and the synthesis of proteins (qv) and acetylcholine. Potassium ions are also believed to function in regulating blood pressure. 

Anaerobic Oxidation of ducose. Historically, the first system of carbohydrate metabolism to be studied was the conversion by yeast of glucose to alcohol (fermentation) according to the equation CnH,Of,2CH)CH,OH + 2CO . The biochemical process is complex, involving the successive catalytic actions of 12 enzymes and known as the Emhden-Meyerhof pathway This series of reactions is summarized in the entry on Glycolysis. 

CONTENTS Acknowledgments, Margery G. Ord and Lloyd A. Stocken. Introduction. Biochemistry Before 1900. Early Metabolic Studies Energy Needs and the Composition of the Diet. Carbohydrate Utilization Glycolysis and Related Activities. Aspects of Carbohydrate Oxidation, Electron Transfer, and Oxidative Phosphorylation. Amino Acid Catabolism in Animals. The Utilization of Fatty Acids. The Impact of Isotopes 1925-1965. Biochemistry and the Cell. Concepts of protein Structure and Function. Chronological Summary of Main Events Up to ca. 1960. Principal Metabolic Pathways. Index. 

When plants experience anoxic conditions there is a shift in carbohydrate metabolism from an oxidative to a fermentative pathway (Fig. 1). In the absence of oxygen, ATP is generated not by the Krebs cycle but by alcoholic fermentation, i.e. glycolysis and ethanol synthesis. 

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